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    ekl-1 Tudor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172444, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ekl-1
    Official Full Name
    Tudor domain-containing protein
    Primary source
    WormBase:WBGene00009052
    Locus tag
    CELE_F22D6.6
    See related
    AllianceGenome:WB:WBGene00009052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in P granule assembly and siRNA processing. Located in condensed nuclear chromosome; cytoplasm; and metaphase plate. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ekl-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (7095486..7098400)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein;Serine/threonine-protein kinase PRP4 homolog Neighboring gene pseudo Neighboring gene 40S ribosomal protein S25 Neighboring gene Serine/threonine-protein phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. om92 , a glp-1 enhancer mutation, is an allele of ekl-1. Stein SA, et al. MicroPubl Biol, 2022. PMID 36530475, Free PMC Article
    2. Regulation of heterochromatin assembly on unpaired chromosomes during Caenorhabditis elegans meiosis by components of a small RNA-mediated pathway. She X, et al. PLoS Genet, 2009 Aug. PMID 19714217, Free PMC Article
    3. The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Claycomb JM, et al. Cell, 2009 Oct 2. PMID 19804758, Free PMC Article
    4. The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. elegans. Davis GM, et al. Elife, 2018 Dec 21. PMID 30575518, Free PMC Article
    5. Epigenetic response to nanopolystyrene in germline of nematode Caenorhabditis elegans. Yang Y, et al. Ecotoxicol Environ Saf, 2020 Dec 15. PMID 33002821

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P granule assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in metaphase plate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tudor domain-containing protein
    NP_492009.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7095486..7098400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059608.6 → NP_492009.1  Tudor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492009.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19731
      Conserved Domains (2) summary
      smart00333
      Location:93 → 149
      TUDOR; Tudor domain
      pfam00567
      Location:48 → 163
      TUDOR; Tudor domain
    Nucleotide Protein
    Heading Accession and Version

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