sur-2 Mediator of RNA polymerase II transcription subunit 23 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sur-2
Official Full Name: Mediator of RNA polymerase II transcription subunit 23
Primary source: WormBase:WBGene00006349
Locus tag: CELE_F39B2.4
See related: AllianceGenome:WB:WBGene00006349
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II. Part of mediator complex. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P6.p hermaphrodite; and vulval cell. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 18. Orthologous to human MED23 (mediator complex subunit 23). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sur-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 17

Sequence:: Chromosome: I; NC_003279.8 (14777137..14787804, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we investigate orthologs of a transcription complex that acts in mammalian EGFR signaling-lin-1/Elk1, sur-2/Med23, and the Cdk8 Kinase module (CKM).our analysis using cell fate reporters reveals that both EGFR and LIN-12/Notch signal transduction pathways are active in all VPCs in lin-1/Elk1 mutants
Title: Integration of EGFR and LIN-12/Notch Signaling by LIN-1/Elk1, the Cdk8 Kinase Module, and SUR-2/Med23 in Vulval Precursor Cell Fate Patterning in Caenorhabditis elegans.
Study shows that sur-2 mutation affects the Cbr-sur-2/MED23 gene that is orthologous to a C. elegans gene critical for the normal response to the EGF signal. whereas Cel-sur-2 mutants exhibit a reduced vulval development because of defects in the VPC immediately adjacent to the anchor cell (the P6.p cell), similar defects in Caenorhabditis briggsae -sur-2 mutants do not have the same impact.
Title: Differing roles for sur-2/MED23 in C. elegans and C. briggsae vulval development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F39B2.3 (e-PCR)
- UniSTS:321457

F39B2.4 (e-PCR)
- UniSTS:321458

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Mediator of RNA polymerase II transcription subunit 23

NP_001021463.1

Confirmed by transcript evidence

NP_493575.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14777137..14787804 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026292.5 → NP_001021463.1 Mediator of RNA polymerase II transcription subunit 23 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021463.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10669

Conserved Domains (2) summary

pfam04487
Location:1409 → 1548

CITED; CITED

pfam11573
Location:25 → 1349

Med23; Mediator complex subunit 23
NM_061174.7 → NP_493575.2 Mediator of RNA polymerase II transcription subunit 23 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493575.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O45497, Q10669, Q9U3G5

Conserved Domains (2) summary

pfam04487
Location:1407 → 1546

CITED; CITED

pfam11573
Location:25 → 1347

Med23; Mediator complex subunit 23