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    drr-2 Serine/arginine-rich splicing factor 2 [ Caenorhabditis elegans ]

    Gene ID: 259546, updated on 9-Dec-2024

    Summary

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    Official Symbol
    drr-2
    Official Full Name
    Serine/arginine-rich splicing factor 2
    Primary source
    WormBase:WBGene00011730
    Locus tag
    CELE_T12D8.2
    See related
    AllianceGenome:WB:WBGene00011730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Part of eukaryotic 48S preinitiation complex. Is expressed in several structures, including coelomocyte; excretory canal; neurons; ventral nerve cord; and vulva. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human EIF4H (eukaryotic translation initiation factor 4H). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See drr-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (13642420..13643570, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Acyl-CoA-binding domain-containing protein 6 Neighboring gene BolA family protein Neighboring gene PHD-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans. Ching TT, et al. Aging Cell, 2010 Aug. PMID 20456299, Free PMC Article
    2. Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Steinkraus KA, et al. Aging Cell, 2008 Jun. PMID 18331616, Free PMC Article
    3. Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Greer EL, et al. Aging Cell, 2009 Apr. PMID 19239417, Free PMC Article
    4. Box C/D small nucleolar ribonucleoproteins regulate mitochondrial surveillance and innate immunity. Tjahjono E, et al. PLoS Genet, 2022 Mar. PMID 35275914, Free PMC Article
    5. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. Hansen M, et al. PLoS Genet, 2005 Jul. PMID 16103914, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA strand annealing activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA strand-exchange activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in eukaryotic translation initiation factor 4F complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic 48S preinitiation complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Serine/arginine-rich splicing factor 2
    NP_499818.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13642420..13643570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067417.4 → NP_499818.1  Serine/arginine-rich splicing factor 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499818.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45781
      Conserved Domains (1) summary
      cl17169
      Location:6 → 88
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version

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