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    catp-2 Cation-transporting P-type ATPase N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 182114, updated on 9-Dec-2024

    Summary

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    Official Symbol
    catp-2
    Official Full Name
    Cation-transporting P-type ATPase N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00015338
    Locus tag
    CELE_C02E7.1
    See related
    AllianceGenome:WB:WBGene00015338
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable P-type sodium:potassium-exchanging transporter activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ATP12A (ATPase H+/K+ transporting non-gastric alpha2 subunit) and ATP4A (ATPase H+/K+ transporting subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See catp-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (4934706..4939085)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Seven TM Receptor Neighboring gene LITAF domain-containing protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Na+/K+ ATPase regulates the expression and localization of acetylcholine receptors in a pump activity-independent manner. Doi M, et al. Mol Cell Neurosci, 2008 Aug. PMID 18599311, Free PMC Article
    2. The Na(+)-K(+)-ATPase is needed in glia of touch receptors for responses to touch in C. elegans. Johnson CK, et al. J Neurophysiol, 2020 May 1. PMID 32292107, Free PMC Article
    3. Exon-dependent transcriptional adaptation by exon-junction complex proteins Y14/RNP-4 and MAGOH/MAG-1 in Caenorhabditis elegans. Fernandez-Abascal J, et al. PLoS Genet, 2022 Oct. PMID 36315586, Free PMC Article
    4. The CHARGE syndrome ortholog CHD-7 regulates TGF-β pathways in Caenorhabditis elegans. Jofré DM, et al. Proc Natl Acad Sci U S A, 2022 Apr 12. PMID 35394881, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type sodium:potassium-exchanging transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment or maintenance of transmembrane electrochemical gradient IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular sodium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cation-transporting P-type ATPase N-terminal domain-containing protein
    NP_001309616.1
    • Partially confirmed by transcript evidence
    NP_504328.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4934706..4939085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071927.2 → NP_504328.1  Cation-transporting P-type ATPase N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16436
      Conserved Domains (1) summary
      cl21460
      Location:66 → 1040
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_001322555.1 → NP_001309616.1  Cation-transporting P-type ATPase N-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBN3
      Conserved Domains (1) summary
      cl21460
      Location:61 → 1035
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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