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    unc-105 Degenerin-like protein unc-105 [ Caenorhabditis elegans ]

    Gene ID: 174306, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-105
    Official Full Name
    Degenerin-like protein unc-105
    Primary source
    WormBase:WBGene00006832
    Locus tag
    CELE_C41C4.5
    See related
    AllianceGenome:WB:WBGene00006832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables monoatomic ion channel activity. Involved in calcium ion transport; magnesium ion transport; and muscle organ development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta); SCNN1D (sodium channel epithelial 1 subunit delta); and SCNN1G (sodium channel epithelial 1 subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-105 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    16
    Sequence:
    Chromosome: II; NC_003280.10 (8116459..8122914)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene eLRR (extracellular Leucine-Rich Repeat) ONly Neighboring gene Endoribonuclease;Serine/threonine-protein kinase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ubiquitin-like protease 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations. García-Añoveros J, et al. Neuron, 1998 Jun. PMID 9655510
    2. The gene structures of spontaneous mutations affecting a Caenorhabditis elegans myosin heavy chain gene. Eide D, et al. Genetics, 1985 Jan. PMID 2981757, Free PMC Article
    3. An amiloride-sensitive H+-gated Na+ channel in Caenorhabditis elegans body wall muscle cells. Jospin M, et al. J Physiol, 2004 Sep 15. PMID 15254157, Free PMC Article
    4. Patch clamp study of the UNC-105 degenerin and its interaction with the LET-2 collagen in Caenorhabditis elegans muscle. Jospin M, et al. J Physiol, 2004 Jun 1. PMID 15020702, Free PMC Article
    5. Caenorhabditis elegans body wall muscles sense mechanical signals with an amiloride-sensitive cation channel. Yan Z, et al. Biochem Biophys Res Commun, 2020 Jun 25. PMID 32423813

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in magnesium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Degenerin-like protein unc-105
    NP_001122595.1
    • Confirmed by transcript evidence
    NP_001254139.1
    • Confirmed by transcript evidence
    NP_001364812.1
    • Confirmed by transcript evidence
    NP_001367274.1
    • Confirmed by transcript evidence
    NP_001368112.1
    • Confirmed by transcript evidence
    NP_495702.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8116459..8122914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377828.2 → NP_001364812.1  Degenerin-like protein unc-105 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLF9
      Conserved Domains (1) summary
      TIGR00867
      Location:119 → 763
      deg-1; degenerin

    2. NM_001381518.2 → NP_001367274.1  Degenerin-like protein unc-105 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E5QCG1
      Conserved Domains (1) summary
      TIGR00867
      Location:13 → 657
      deg-1; degenerin

    3. NM_001381517.1 → NP_001368112.1  Degenerin-like protein unc-105 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLF8
      Conserved Domains (1) summary
      TIGR00867
      Location:119 → 763
      deg-1; degenerin

    4. NM_001267210.3 → NP_001254139.1  Degenerin-like protein unc-105 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254139.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLG0
      Conserved Domains (2) summary
      TIGR00867
      Location:119 → 763
      deg-1; degenerin
      cl02990
      Location:119 → 764
      ASC; Amiloride-sensitive sodium channel

    5. NM_063301.6 → NP_495702.1  Degenerin-like protein unc-105 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495702.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09274
      Conserved Domains (2) summary
      TIGR00867
      Location:33 → 677
      deg-1; degenerin
      cl02990
      Location:33 → 704
      ASC; Amiloride-sensitive sodium channel

    6. NM_001129123.3 → NP_001122595.1  Degenerin-like protein unc-105 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122595.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A3FPK3, Q09274
      Conserved Domains (2) summary
      TIGR00867
      Location:71 → 715
      deg-1; degenerin
      cl02990
      Location:71 → 742
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09274.3

    Gene LinkOut

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