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    Y43F8B.3 BPTI/Kunitz inhibitor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180277, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y43F8B.3
    Official Full Name
    BPTI/Kunitz inhibitor domain-containing protein
    Primary source
    WormBase:WBGene00012814
    Locus tag
    CELE_Y43F8B.3
    See related
    AllianceGenome:WB:WBGene00012814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y43F8B.3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    25
    Sequence:
    Chromosome: V; NC_003283.11 (19503101..19520015)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene SCP domain-containing protein Neighboring gene Fe2OG dioxygenase domain-containing protein Neighboring gene Fe2OG dioxygenase domain-containing protein Neighboring gene ncRNA Neighboring gene GSKIP domain-containing protein Neighboring gene MIF4G domain-containing protein;Prion-like-(Q/N-rich)-domain-bearing protein;Titin;ZM domain-containing protein Neighboring gene ncRNA Neighboring gene DUF19 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BPTI/Kunitz inhibitor domain-containing protein
    NP_001123046.2
    • Confirmed by transcript evidence
    NP_001123047.2
    • Confirmed by transcript evidence
    NP_001256870.1
    • Partially confirmed by transcript evidence
    NP_001256871.1
    • Confirmed by transcript evidence
    NP_001256872.1
    • Confirmed by transcript evidence
    NP_001256873.1
    • Confirmed by transcript evidence
    NP_001256874.1
    • Confirmed by transcript evidence
    NP_001263941.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      19503101..19520015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269942.4 → NP_001256871.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256871.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0Z3L4
      Conserved Domains (4) summary
      smart00131
      Location:438 → 490
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:861 → 912
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:497 → 540
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain

    2. NM_001269943.4 → NP_001256872.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256872.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KMJ6
      Conserved Domains (4) summary
      smart00131
      Location:383 → 435
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:806 → 857
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:442 → 485
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain

    3. NM_001129574.5 → NP_001123046.2  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123046.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWX5
      Conserved Domains (4) summary
      smart00131
      Location:438 → 490
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:855 → 907
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:497 → 540
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain

    4. NM_001277012.3 → NP_001263941.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263941.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8FDZ2
      Conserved Domains (3) summary
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:388 → 439
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:338 → 380
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain

    5. NM_001269944.3 → NP_001256873.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256873.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KMJ9
      Conserved Domains (4) summary
      smart00131
      Location:383 → 435
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:800 → 852
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:442 → 485
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain

    6. NM_001269941.3 → NP_001256870.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256870.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KMJ7
      Conserved Domains (5) summary
      smart00131
      Location:521 → 573
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:944 → 995
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:580 → 623
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
      cl00101
      Location:180 → 231
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    7. NM_001129575.4 → NP_001123047.2  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123047.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5HW96
      Conserved Domains (4) summary
      smart00131
      Location:438 → 490
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:855 → 907
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:497 → 540
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain

    8. NM_001269945.3 → NP_001256874.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256874.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0Z3L5
      Conserved Domains (4) summary
      smart00131
      Location:438 → 490
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00109
      Location:76 → 126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:861 → 912
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:497 → 540
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
    Nucleotide Protein
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