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    • Showing Current items.

    rfc-3 Replication factor C subunit 3 [ Caenorhabditis elegans ]

    Gene ID: 178259, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rfc-3
    Official Full Name
    Replication factor C subunit 3
    Primary source
    WormBase:WBGene00004339
    Locus tag
    CELE_C39E9.13
    See related
    AllianceGenome:WB:WBGene00004339
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity and DNA binding activity. Predicted to contribute to DNA clamp loader activity. Predicted to be involved in DNA repair and DNA-templated DNA replication. Predicted to be part of DNA replication factor C complex. Predicted to be active in nucleus. Orthologous to human RFC3 (replication factor C subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rfc-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (13095762..13096997)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Proline-rich protein PRCC Neighboring gene SAP domain-containing protein Neighboring gene Dynein light intermediate chain Neighboring gene Putative exosome complex component RRP41 Neighboring gene Mitochondrial import inner membrane translocase subunit Tim10B Neighboring gene RAP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic Analysis Reveals JAK2/MPL-Independent Effects of Calreticulin Mutations in a C. elegans Model. Guijarro-Hernández A, et al. Cells, 2023 Jan 2. PMID 36611979, Free PMC Article
    2. Combined functional genomic maps of the C. elegans DNA damage response. Boulton SJ, et al. Science, 2002 Jan 4. PMID 11778048
    3. Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Pothof J, et al. Genes Dev, 2003 Feb 15. PMID 12600937, Free PMC Article
    4. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
    5. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication factor C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Replication factor C subunit 3
    NP_502517.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13095762..13096997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070116.9 → NP_502517.1  Replication factor C subunit 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502517.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18547
      Conserved Domains (3) summary
      cd00009
      Location:38 → 187
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      PRK12402
      Location:3 → 342
      PRK12402; replication factor C small subunit 2; Reviewed
      pfam08542
      Location:253 → 340
      Rep_fac_C; Replication factor C C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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