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    gpa-6 Guanine nucleotide-binding protein alpha-6 subunit [ Caenorhabditis elegans ]

    Gene ID: 181442, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpa-6
    Official Full Name
    Guanine nucleotide-binding protein alpha-6 subunit
    Primary source
    WormBase:WBGene00001668
    Locus tag
    CELE_F48C11.1
    See related
    AllianceGenome:WB:WBGene00001668
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in axon and neuronal cell body. Is expressed in head mesodermal cell; intestine; and nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpa-6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (13191212..13194390)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene Coexpressed With Polycystins Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronal Chemosensation and Osmotic Stress Response Converge in the Regulation of aqp-8 in C. elegans. Igual Gil C, et al. Front Physiol, 2017. PMID 28649202, Free PMC Article
    2. A network of stimulatory and inhibitory Galpha-subunits regulates olfaction in Caenorhabditis elegans. Lans H, et al. Genetics, 2004 Aug. PMID 15342507, Free PMC Article
    3. Multiple olfactory pathways contribute to the lure process of Caenorhabditis elegans by pathogenic bacteria. Zhu M, et al. Sci China Life Sci, 2021 Aug. PMID 33263920
    4. Reverse genetics by chemical mutagenesis in Caenorhabditis elegans. Jansen G, et al. Nat Genet, 1997 Sep. PMID 9288111
    5. Integration of spatially opposing cues by a single interneuron guides decision-making in C. elegans. Gat A, et al. Cell Rep, 2023 Sep 26. PMID 37691148

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Guanine nucleotide-binding protein alpha-6 subunit
    NP_510189.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13191212..13194390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077788.2 → NP_510189.1  Guanine nucleotide-binding protein alpha-6 subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510189.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93743
      Conserved Domains (2) summary
      cd00066
      Location:43 → 357
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:22 → 361
      G_alpha; G protein alpha subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93743.2

    Gene LinkOut

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