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    catp-4 Sodium/potassium-transporting ATPase subunit alpha [ Caenorhabditis elegans ]

    Gene ID: 175120, updated on 9-Dec-2024

    Summary

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    Official Symbol
    catp-4
    Official Full Name
    Sodium/potassium-transporting ATPase subunit alpha
    Primary source
    WormBase:WBGene00007248
    Locus tag
    CELE_C01G12.8
    See related
    AllianceGenome:WB:WBGene00007248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable P-type sodium:potassium-exchanging transporter activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See catp-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (14593581..14597657)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Nematode Specific Peptide family, group B Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2;Trehalose-6-phosphate phosphatase C-terminal domain-containing protein Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insights into the genetic influences of the microbiota on the life span of a host. Zhang F, et al. Front Microbiol, 2023. PMID 37601381, Free PMC Article
    2. Na+/K+ ATPase regulates the expression and localization of acetylcholine receptors in a pump activity-independent manner. Doi M, et al. Mol Cell Neurosci, 2008 Aug. PMID 18599311, Free PMC Article
    3. The Na(+)-K(+)-ATPase is needed in glia of touch receptors for responses to touch in C. elegans. Johnson CK, et al. J Neurophysiol, 2020 May 1. PMID 32292107, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type potassium transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type sodium:potassium-exchanging transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment or maintenance of transmembrane electrochemical gradient IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular sodium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sodium/potassium-transporting ATPase subunit alpha
    NP_497034.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14593581..14597657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064633.5 → NP_497034.2  Sodium/potassium-transporting ATPase subunit alpha [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFV6
      Conserved Domains (6) summary
      smart00831
      Location:24 → 95
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      TIGR01106
      Location:9 → 1015
      ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
      pfam00122
      Location:118 → 349
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:791 → 1000
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam12710
      Location:582 → 718
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:414 → 507
      Cation_ATPase; Cation transport ATPase (P-type)
    Nucleotide Protein
    Heading Accession and Version

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