obr-3 PH domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: obr-3
Official Full Name: PH domain-containing protein
Primary source: WormBase:WBGene00014215
Locus tag: CELE_ZK1086.1
See related: AllianceGenome:WB:WBGene00014215
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cholesterol binding activity. Involved in regulation of growth and transforming growth factor beta receptor signaling pathway. Predicted to be active in cytosol and membrane. Is expressed in hypodermis; neurons; and pharyngeal muscle cell. Orthologous to human OSBPL5 (oxysterol binding protein like 5) and OSBPL8 (oxysterol binding protein like 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See obr-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 12

Sequence:: Chromosome: X; NC_003284.9 (13798210..13809873, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK1086.1 (e-PCR)
- UniSTS:313671

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: PH domain-containing protein

NP_001379311.1

Confirmed by transcript evidence

NP_741923.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

13798210..13809873 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171794.7 → NP_741923.1 PH domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741923.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EC19

Conserved Domains (2) summary

cd13286
Location:33 → 165

PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain

pfam01237
Location:271 → 599

Oxysterol_BP; Oxysterol-binding protein
NM_001392877.1 → NP_001379311.1 PH domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8MPR9

Conserved Domains (2) summary

cd13286
Location:70 → 202

PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain

pfam01237
Location:308 → 631

Oxysterol_BP; Oxysterol-binding protein