sams-5 putative S-adenosylmethionine synthase 5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sams-5
Official Full Name: putative S-adenosylmethionine synthase 5
Primary source: WormBase:WBGene00006416
Locus tag: CELE_T13A10.11
See related: AllianceGenome:WB:WBGene00006416
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable methionine adenosyltransferase activity. Predicted to be involved in S-adenosylmethionine biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including excretory gland cell; intestine; pharyngeal neurons; rectal gland cell; and reproductive system. Human ortholog(s) of this gene implicated in hypermethioninemia and lung cancer. Orthologous to human MAT1A (methionine adenosyltransferase 1A) and MAT2A (methionine adenosyltransferase 2A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sams-5 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (6277436..6279522, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S-adenosyl methionine synthetase SAMS-5 mediates dietary restriction-induced longevity in Caenorhabditis elegans.
Title: S-adenosyl methionine synthetase SAMS-5 mediates dietary restriction-induced longevity in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T13A10.11 (e-PCR)
- UniSTS:310827

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methionine adenosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionine adenosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in S-adenosylmethionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative S-adenosylmethionine synthase 5

NP_741415.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6277436..6279522 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171354.6 → NP_741415.1 putative S-adenosylmethionine synthase 5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741415.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27522

Conserved Domains (4) summary

PTZ00104
Location:1 → 387

PTZ00104; S-adenosylmethionine synthase; Provisional

pfam00438
Location:5 → 102

S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain

pfam02772
Location:117 → 238

S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain

pfam02773
Location:240 → 376

S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain