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    del-1 Amiloride-sensitive sodium channel subunit alpha;Degenerin del-1 [ Caenorhabditis elegans ]

    Gene ID: 181534, updated on 9-Dec-2024

    Summary

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    Official Symbol
    del-1
    Official Full Name
    Amiloride-sensitive sodium channel subunit alpha;Degenerin del-1
    Primary source
    WormBase:WBGene00000952
    Locus tag
    CELE_E02H4.1
    See related
    AllianceGenome:WB:WBGene00000952
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nervous system and in male. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta); SCNN1D (sodium channel epithelial 1 subunit delta); and SCNN1G (sodium channel epithelial 1 subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See del-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    18
    Sequence:
    Chromosome: X; NC_003284.9 (14268081..14277082)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Vegetative cell wall protein gp1-like Neighboring gene ncRNA Neighboring gene MIF4G domain-containing protein Neighboring gene Protein kinase domain-containing protein;putative dual specificity protein kinase madd-3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. unc-8, a DEG/ENaC family member, encodes a subunit of a candidate mechanically gated channel that modulates C. elegans locomotion. Tavernarakis N, et al. Neuron, 1997 Jan. PMID 9010209
    2. UNC-4/UNC-37-dependent repression of motor neuron-specific genes controls synaptic choice in Caenorhabditis elegans. Winnier AR, et al. Genes Dev, 1999 Nov 1. PMID 10557206, Free PMC Article
    3. Caenorhabditis elegans degenerins and vertebrate ENaC ion channels contain an extracellular domain related to venom neurotoxins. Tavernarakis N, et al. J Neurogenet, 2000 Jan. PMID 10858823
    4. Parallel Processing of Two Mechanosensory Modalities by a Single Neuron in C. elegans. Tao L, et al. Dev Cell, 2019 Dec 2. PMID 31735664, Free PMC Article
    5. DEG/ENaC/ASIC channels vary in their sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs. Fechner S, et al. J Gen Physiol, 2021 Apr 5. PMID 33656557, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Amiloride-sensitive sodium channel subunit alpha;Degenerin del-1
    NP_001355359.1
    • Confirmed by transcript evidence
    NP_001355470.1
    • Confirmed by transcript evidence
    NP_001355471.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14268081..14277082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001368544.2 → NP_001355359.1  Degenerin del-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19038
      Conserved Domains (1) summary
      TIGR00867
      Location:75 → 656
      deg-1; degenerin

    2. NM_001368545.4 → NP_001355470.1  Degenerin del-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19038
      UniProtKB/TrEMBL
      A0A3B1DQL6
      Conserved Domains (1) summary
      TIGR00867
      Location:50 → 631
      deg-1; degenerin

    3. NM_001368546.2 → NP_001355471.1  Amiloride-sensitive sodium channel subunit alpha [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19038
      UniProtKB/TrEMBL
      A0A3B1E9Z7
      Conserved Domains (1) summary
      TIGR00867
      Location:30 → 611
      deg-1; degenerin
    Nucleotide Protein
    Heading Accession and Version

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