lat-1 Latrophilin-like protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lat-1
Official Full Name: Latrophilin-like protein 1
Primary source: WormBase:WBGene00002251
Locus tag: CELE_B0457.1
See related: AllianceGenome:WB:WBGene00002251
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables endopeptidase activity. Involved in several processes, including anterior/posterior pattern specification; embryo development; and self proteolysis. Located in plasma membrane. Is expressed in several structures, including ABarppaapa; Caaaaa; neurons; pharynx; and reproductive system. Orthologous to several human genes including ADGRL3 (adhesion G protein-coupled receptor L3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lat-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 9

Sequence:: Chromosome: II; NC_003280.10 (8896841..8908634)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Latrophilin-1 drives neuron morphogenesis and shapes chemo- and mechanosensation-dependent behavior in C. elegans via a trans function.
Title: Latrophilin-1 drives neuron morphogenesis and shapes chemo- and mechanosensation-dependent behavior in C. elegans via a trans function.
Our data support a model in which a novel, GPCR-dependent G protein-signaling cascade mediated by LAT-1 controls alignment of cell division planes in an anterior-posterior direction via a metabotropic Gs-protein
Title: Oriented Cell Division in the C. elegans Embryo Is Coordinated by G-Protein Signaling Dependent on the Adhesion GPCR LAT-1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0457.1 (e-PCR)
- UniSTS:321164

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in self proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in sexual reproduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sexual reproduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Latrophilin-like protein 1

NP_001366731.1

Confirmed by transcript evidence

NP_001367041.1

Confirmed by transcript evidence

NP_001379413.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8896841..8908634

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381541.2 → NP_001367041.1 Latrophilin-like protein 1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (5) summary

smart00303
Location:491 → 539

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:178 → 242

HormR; Domain present in hormone receptors

cd15440
Location:546 → 806

7tmB2_latrophilin-like_invertebrate; invertebrate latrophilin-like receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:51 → 132

Gal_Lectin; Galactose binding lectin domain

pfam16489
Location:256 → 460

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
NM_001381542.3 → NP_001366731.1 Latrophilin-like protein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EDW2, G5EEH7, Q7JM97

Conserved Domains (5) summary

smart00303
Location:493 → 541

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:180 → 244

HormR; Domain present in hormone receptors

cd15440
Location:548 → 808

7tmB2_latrophilin-like_invertebrate; invertebrate latrophilin-like receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:51 → 133

Gal_Lectin; Galactose binding lectin domain

pfam16489
Location:258 → 462

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
NM_001393142.1 → NP_001379413.1 Latrophilin-like protein 1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

pfam02140
Location:51 → 99

Gal_Lectin; Galactose binding lectin domain