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    max-1 PH domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179794, updated on 9-Dec-2024

    Summary

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    Official Symbol
    max-1
    Official Full Name
    PH domain-containing protein
    Primary source
    WormBase:WBGene00003143
    Locus tag
    CELE_C34B4.1
    See related
    AllianceGenome:WB:WBGene00003143
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in motor neuron axon guidance. Predicted to be located in cytoskeleton. Is expressed in neurons. Orthologous to human PLEKHH1 (pleckstrin homology, MyTH4 and FERM domain containing H1) and PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See max-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (13098914..13110337, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vertebrate MAX-1 is required for vascular patterning in zebrafish. Zhong H, et al. Proc Natl Acad Sci U S A, 2006 Nov 7. PMID 17065323, Free PMC Article
    2. Regulation of axon repulsion by MAX-1 SUMOylation and AP-3. Chen SY, et al. Proc Natl Acad Sci U S A, 2018 Aug 28. PMID 30104385, Free PMC Article
    3. The PH/MyTH4/FERM molecule MAX-1 inhibits UNC-5 activity in the regulation of VD growth cone protrusion in Caenorhabditis elegans. Mahadik SS, et al. Genetics, 2022 May 5. PMID 35348689, Free PMC Article
    4. Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling. Chen SY, et al. Proc Natl Acad Sci U S A, 2011 Apr 5. PMID 21422296, Free PMC Article
    5. The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance. Lucanic M, et al. Development, 2006 Nov. PMID 17050621

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in motor neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PH domain-containing protein
    NP_001367137.1
    • Confirmed by transcript evidence
    NP_001379161.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13098914..13110337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392634.1 → NP_001379161.1  PH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18420, Q8MTP4
      Conserved Domains (4) summary
      smart00233
      Location:249 → 346
      PH; Pleckstrin homology domain
      smart00295
      Location:677 → 892
      B41; Band 4.1 homologues
      pfam00784
      Location:558 → 662
      MyTH4; MyTH4 domain
      cl17171
      Location:888 → 984
      PH-like; Pleckstrin homology-like domain

    2. NM_001380794.1 → NP_001367137.1  PH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED24, Q8MTP4
      Conserved Domains (4) summary
      smart00233
      Location:353 → 450
      PH; Pleckstrin homology domain
      smart00295
      Location:781 → 996
      B41; Band 4.1 homologues
      pfam00784
      Location:662 → 766
      MyTH4; MyTH4 domain
      cl17171
      Location:992 → 1088
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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