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    acs-22 Long-chain-fatty-acid--CoA ligase [ Caenorhabditis elegans ]

    Gene ID: 181138, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acs-22
    Official Full Name
    Long-chain-fatty-acid--CoA ligase
    Primary source
    WormBase:WBGene00017012
    Locus tag
    CELE_D1009.1
    See related
    AllianceGenome:WB:WBGene00017012
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable long-chain fatty acid transmembrane transporter activity and long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid import into cell and long-chain fatty acid metabolic process. Located in endoplasmic reticulum. Is expressed in head neurons; hypodermis; intestine; and pharynx. Orthologous to human SLC27A1 (solute carrier family 27 member 1) and SLC27A4 (solute carrier family 27 member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acs-22 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (8931179..8939263)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene tRNA-Gln Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene Tctex1 domain-containing protein 2 Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Trp

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two very long chain fatty acid acyl-CoA synthetase genes, acs-20 and acs-22, have roles in the cuticle surface barrier in Caenorhabditis elegans. Kage-Nakadai E, et al. PLoS One, 2010 Jan 25. PMID 20111596, Free PMC Article
    2. Damage on functional state of intestinal barrier by microgravity stress in nematode Caenorhabditis elegans. Liu H, et al. Ecotoxicol Environ Saf, 2019 Nov 15. PMID 31434019
    3. Lactic Acid Bacteria Protects Caenorhabditis elegans from Toxicity of Graphene Oxide by Maintaining Normal Intestinal Permeability under different Genetic Backgrounds. Zhao Y, et al. Sci Rep, 2015 Nov 27. PMID 26611622, Free PMC Article
    4. The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface. Xu N, et al. J Cell Biol, 2012 Sep 3. PMID 22927462, Free PMC Article
    5. A Genetic Screen for Mutants with Supersized Lipid Droplets in Caenorhabditis elegans. Li S, et al. G3 (Bethesda), 2016 Aug 9. PMID 27261001, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in long-chain fatty acid import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Long-chain-fatty-acid--CoA ligase
    NP_001309684.1
    • Confirmed by transcript evidence
    NP_001380195.1
    • Confirmed by transcript evidence
    NP_509509.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8931179..8939263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077108.6 → NP_509509.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509509.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18916
      Conserved Domains (2) summary
      cd05939
      Location:105 → 618
      hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
      PRK08279
      Location:49 → 650
      PRK08279; long-chain-acyl-CoA synthetase; Validated

    2. NM_001392815.1 → NP_001380195.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBB2
      Conserved Domains (1) summary
      cd05939
      Location:102 → 615
      hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins

    3. NM_001322629.4 → NP_001309684.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MB92
      Conserved Domains (2) summary
      PRK12406
      Location:2 → 505
      PRK12406; long-chain-fatty-acid--CoA ligase; Provisional
      cl17068
      Location:1 → 488
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein
    Heading Accession and Version

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