U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nuo-5 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 178735, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nuo-5
    Official Full Name
    NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
    Primary source
    WormBase:WBGene00021562
    Locus tag
    CELE_Y45G12B.1
    See related
    AllianceGenome:WB:WBGene00021562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity and oxidoreductase activity, acting on NAD(P)H. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in respiratory electron transport chain. Predicted to be part of respiratory chain complex I. Predicted to be active in membrane. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See nuo-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (2698972..2706984)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene BACK domain-containing protein;BTB domain-containing protein;Kelch-like protein 8 Neighboring gene L-2-hydroxyglutarate dehydrogenase, mitochondrial Neighboring gene Zinc finger protein-like 1 homolog Neighboring gene VWFA domain-containing protein Neighboring gene ncRNA Neighboring gene G protein-coupled receptor;Serpentine Receptor, class T

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetic modulators associated with regulatory surveillance of mitochondrial quality control, play a key role in regulating stress pathways and longevity in C. elegans. Sarkar A, et al. Life Sci, 2022 Feb 1. PMID 34953889
    2. Phloretin prolongs lifespan of Caenorhabditis elegans via inhibition of NDUFS1 and NDUFS6 at mitochondrial complex Ⅰ. Zhang Y, et al. Free Radic Biol Med, 2024 Aug 20. PMID 38705496
    3. Subcomplex Ilambda specifically controls integrated mitochondrial functions in Caenorhabditis elegans. Falk MJ, et al. PLoS One, 2009 Aug 12. PMID 19672299, Free PMC Article
    4. Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans. Maglioni S, et al. Nat Commun, 2022 May 12. PMID 35551180, Free PMC Article
    5. Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans. Sladowska M, et al. PLoS Biol, 2021 Jul. PMID 34252079, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
    NP_503733.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      2698972..2706984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071332.7 → NP_503733.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503733.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4Y8
      Conserved Domains (5) summary
      PRK09130
      Location:32 → 717
      PRK09130; NADH dehydrogenase subunit G; Validated
      cd02773
      Location:252 → 630
      MopB_Res-Cmplx1_Nad11; MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase ...
      pfam09326
      Location:672 → 707
      NADH_dhqG_C; NADH-ubiquinone oxidoreductase subunit G, C-terminal
      pfam10588
      Location:113 → 152
      NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
      pfam13510
      Location:30 → 106
      Fer2_4; 2Fe-2S iron-sulfur cluster binding domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools