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    upb-1 CN hydrolase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174040, updated on 9-Dec-2024

    Summary

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    Official Symbol
    upb-1
    Official Full Name
    CN hydrolase domain-containing protein
    Primary source
    WormBase:WBGene00017440
    Locus tag
    CELE_F13H8.7
    See related
    AllianceGenome:WB:WBGene00017440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables beta-ureidopropionase activity. Involved in beta-alanine biosynthetic process via 3-ureidopropionate; thymine catabolic process; and uracil catabolic process. Located in striated muscle dense body. Is expressed in body wall musculature. Orthologous to human UPB1 (beta-ureidopropionase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See upb-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (6288412..6290097, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Enhancer of polycomb-like protein Neighboring gene DUF4238 domain-containing protein Neighboring gene RNase NYN domain-containing protein Neighboring gene MiRP K channel accessory Subunit Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The 3-ureidopropionase of Caenorhabditis elegans, an enzyme involved in pyrimidine degradation. Janowitz T, et al. FEBS J, 2010 Oct. PMID 20840592
    2. Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor. Bar DZ, et al. Proc Natl Acad Sci U S A, 2016 Aug 9. PMID 27457958, Free PMC Article
    3. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article
    4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables beta-ureidopropionase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-ureidopropionase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in beta-alanine biosynthetic process via 3-ureidopropionate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in beta-alanine biosynthetic process via 3-ureidopropionate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thymine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in uracil catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CN hydrolase domain-containing protein
    NP_495261.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6288412..6290097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062860.5 → NP_495261.1  CN hydrolase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495261.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19437
      Conserved Domains (1) summary
      cd07587
      Location:11 → 373
      ML_beta-AS; mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases)
    Nucleotide Protein
    Heading Accession and Version

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