egl-2 Potassium voltage-gated channel protein eag [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: egl-2
Official Full Name: Potassium voltage-gated channel protein eag
Primary source: WormBase:WBGene00001171
Locus tag: CELE_F16B3.1
See related: AllianceGenome:WB:WBGene00001171
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein kinase binding activity. Involved in chemosensory behavior; egg-laying behavior; and muscle contraction. Located in microvillus membrane. Is expressed in intestinal cell; nervous system; vulval muscle; and in male. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma and developmental and epileptic encephalopathy. Orthologous to several human genes including KCNH5 (potassium voltage-gated channel subfamily H member 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See egl-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 15

Sequence:: Chromosome: V; NC_003283.11 (1289373..1299332, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An interaction between BK and EAG family K(+) channels produces the muscle excitability levels that regulate the timing of spicule protraction and the success of male mating behavior.
Title: Cell excitability necessary for male mating behavior in Caenorhabditis elegans is coordinated by interactions between big current and ether-a-go-go family K(+) channels.
Increased expression of ether-a-go-go potassium channel egl-2 in the male sex muscles, in response to a period of transient starvation, produces lasting consequences in the excitability of the male mating circuit.
Title: The effects of transient starvation persist through direct interactions between CaMKII and ether-a-go-go K+ channels in C. elegans males.
The tricyclic antidepressant imipramine inhibits both egl-2 and its mouse counterpart M-eag.
Title: Block of an ether-a-go-go-like K(+) channel by imipramine rescues egl-2 excitation defects in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F16B3.1 (e-PCR)
- UniSTS:309788

STS5-37 (e-PCR)
- UniSTS:242466

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of metabolic process	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IC Inferred by Curator more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus membrane	IDA Inferred from Direct Assay more info	PubMed
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Potassium voltage-gated channel protein eag

NP_001368562.1

Confirmed by transcript evidence

NP_503402.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

1289373..1299332 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071001.5 → NP_503402.3 Potassium voltage-gated channel protein eag [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503402.3

Status: REVIEWED

UniProtKB/TrEMBL

O44164, Q9XYX7

Conserved Domains (6) summary

COG0664
Location:561 → 699

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:568 → 679

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00130
Location:42 → 133

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00520
Location:266 → 495

Ion_trans; Ion transport protein

pfam07885
Location:436 → 490

Ion_trans_2; Ion channel

pfam13426
Location:27 → 134

PAS_9; PAS domain
NM_001380597.1 → NP_001368562.1 Potassium voltage-gated channel protein eag [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AVF4, Q9XYX7

Conserved Domains (3) summary

PLN03192
Location:177 → 635

PLN03192; Voltage-dependent potassium channel; Provisional

TIGR03896
Location:594 → 694

cyc_nuc_ocin; bacteriocin-type transport-associated protein

pfam13426
Location:27 → 134

PAS_9; PAS domain