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    ugt-21 UDP-glucuronosyltransferase [ Caenorhabditis elegans ]

    Gene ID: 183141, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ugt-21
    Official Full Name
    UDP-glucuronosyltransferase
    Primary source
    WormBase:WBGene00007885
    Locus tag
    CELE_C33A12.6
    See related
    AllianceGenome:WB:WBGene00007885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Orthologous to human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ugt-21 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (9500311..9502574)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class U Neighboring gene Serpentine Receptor, class U Neighboring gene pseudo Neighboring gene TransThyretin-Related family domain Neighboring gene Metallo-beta-lactamase domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Xenobiotic detoxification in the nematode Caenorhabditis elegans. Lindblom TH, et al. J Exp Zool A Comp Exp Biol, 2006 Sep 1. PMID 16902959, Free PMC Article
    2. A systems biology analysis of reproductive toxicity effects induced by multigenerational exposure to ionizing radiation in C. elegans. Guédon R, et al. Ecotoxicol Environ Saf, 2021 Dec 1. PMID 34544019
    3. UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences. Matoušková P, et al. Int J Parasitol Drugs Drug Resist, 2018 Dec. PMID 30293057, Free PMC Article
    4. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables UDP-glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucuronosyltransferase
    NP_001293944.1
    • Confirmed by transcript evidence
    NP_501680.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9500311..9502574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069279.5 → NP_501680.2  UDP-glucuronosyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501680.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18361
      Conserved Domains (1) summary
      cd03784
      Location:20 → 465
      GT1_Gtf-like; UDP-glycosyltransferases and similar proteins

    2. NM_001307015.3 → NP_001293944.1  UDP-glucuronosyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293944.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AKV1
      Conserved Domains (2) summary
      PHA03392
      Location:263 → 504
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:32 → 526
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    Nucleotide Protein
    Heading Accession and Version

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