cnt-2 Arf-GAP with ANK repeat and PH domain-containing protein cnt-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cnt-2
Official Full Name: Arf-GAP with ANK repeat and PH domain-containing protein cnt-2
Primary source: WormBase:WBGene00000566
Locus tag: CELE_Y39A1A.15
See related: AllianceGenome:WB:WBGene00000566
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activator activity and GTPase activity. Involved in asymmetric neuroblast division; cell fate determination involved in pattern specification; and regulation of receptor-mediated endocytosis. Is expressed in body wall musculature; intestine; pharynx; seam cell; and tail. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cnt-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 15

Sequence:: Chromosome: III; NC_003281.10 (10655018..10677522)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CNT-2 regulates receptor-mediated endocytosis and consider the implications of its role in asymmetric cell divisions.
Title: The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y39A1A.15 (e-PCR)
- UniSTS:317544

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in asymmetric neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate determination involved in pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of receptor-mediated endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Arf-GAP with ANK repeat and PH domain-containing protein cnt-2

NP_001022836.1

Confirmed by transcript evidence

NP_001022837.1

Confirmed by transcript evidence

NP_001022838.1

Confirmed by transcript evidence

NP_001380212.1

Confirmed by transcript evidence

NP_001380213.1

Confirmed by transcript evidence

NP_001380214.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10655018..10677522

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027666.6 → NP_001022837.1 Arf-GAP with ANK repeat and PH domain-containing protein cnt-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022837.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XX14

Conserved Domains (8) summary

cd04103
Location:79 → 237

Centaurin_gamma; Centaurin gamma (CENTG) GTPase

smart00175
Location:79 → 240

RAB; Rab subfamily of small GTPases

cd00204
Location:793 → 878

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01250
Location:452 → 650

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

pfam00169
Location:455 → 517

PH; PH domain

pfam01412
Location:669 → 782

ArfGap; Putative GTPase activating protein for Arf

pfam12796
Location:793 → 886

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:793 → 822

ANK; ANK repeat [structural motif]
NM_001392201.1 → NP_001380212.1 Arf-GAP with ANK repeat and PH domain-containing protein cnt-2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1X7RBL4

Conserved Domains (5) summary

cd04103
Location:1 → 159

Centaurin_gamma; Centaurin gamma (CENTG) GTPase

cd01250
Location:374 → 572

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

sd00045
Location:715 → 744

ANK; ANK repeat [structural motif]

cd08836
Location:589 → 697

ArfGap_AGAP; ArfGAP with GTPase domain, ANK repeat and PH domains

pfam12796
Location:715 → 807

Ank_2; Ankyrin repeats (3 copies)
NM_001027665.4 → NP_001022836.1 Arf-GAP with ANK repeat and PH domain-containing protein cnt-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022836.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U2M2, Q9XX09, Q9XX14, Q9XZQ3, Q9XZQ4

Conserved Domains (5) summary

cd04103
Location:235 → 393

Centaurin_gamma; Centaurin gamma (CENTG) GTPase

cd00204
Location:949 → 1034

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01250
Location:608 → 806

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

sd00045
Location:949 → 978

ANK; ANK repeat [structural motif]

pfam01412
Location:825 → 938

ArfGap; Putative GTPase activating protein for Arf
NM_001027667.6 → NP_001022838.1 Arf-GAP with ANK repeat and PH domain-containing protein cnt-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022838.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XX14

Conserved Domains (8) summary

cd04103
Location:32 → 189

Centaurin_gamma; Centaurin gamma (CENTG) GTPase

smart00175
Location:31 → 192

RAB; Rab subfamily of small GTPases

cd00204
Location:745 → 830

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01250
Location:404 → 602

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

pfam00169
Location:407 → 469

PH; PH domain

pfam01412
Location:621 → 734

ArfGap; Putative GTPase activating protein for Arf

pfam12796
Location:745 → 838

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:745 → 774

ANK; ANK repeat [structural motif]
NM_001392202.1 → NP_001380213.1 Arf-GAP with ANK repeat and PH domain-containing protein cnt-2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1X7RBL1

Conserved Domains (5) summary

cd01250
Location:243 → 441

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

sd00045
Location:584 → 613

ANK; ANK repeat [structural motif]

cd08836
Location:458 → 566

ArfGap_AGAP; ArfGAP with GTPase domain, ANK repeat and PH domains

pfam12796
Location:584 → 676

Ank_2; Ankyrin repeats (3 copies)

cl38936
Location:1 → 28

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001392203.1 → NP_001380214.1 Arf-GAP with ANK repeat and PH domain-containing protein cnt-2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1X7RC73

Conserved Domains (4) summary

cd01250
Location:167 → 365

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

sd00045
Location:508 → 537

ANK; ANK repeat [structural motif]

cd08836
Location:382 → 490

ArfGap_AGAP; ArfGAP with GTPase domain, ANK repeat and PH domains

pfam12796
Location:508 → 600

Ank_2; Ankyrin repeats (3 copies)