ttr-52 Transthyretin-like protein 52 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ttr-52
Official Full Name: Transthyretin-like protein 52
Primary source: WormBase:WBGene00008719
Locus tag: CELE_F11F1.7
See related: AllianceGenome:WB:WBGene00008719
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables several functions, including phosphatidylserine binding activity; protein homodimerization activity; and scavenger receptor binding activity. Involved in aminophospholipid transport; apoptotic process involved in development; and recognition of apoptotic cell. Located in cell surface and extracellular vesicle. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ttr-52 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (13404718..13405783)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CED-7 and TTR-52 may promote the efflux of PS from apoptotic cells through the generation of extracellular phosphatidylserine (PS) vesicles, which lead to exoplasmic leaflet (exPS) expression on phagocytes via TTR-52 and CED-1 to facilitate cell corpse clearance.
Title: CED-1, CED-7, and TTR-52 regulate surface phosphatidylserine expression on apoptotic and phagocytic cells.
The structural and functional studies of Caenorhabditis elegans TTR-52, a recently identified bridging molecule that cross-links surface-exposed phosphatidylserine (PtdSer) on apoptotic cells to the CED-1 receptor on phagocytes, is reported.
Title: Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment.
TTR-52 is therefore the first bridging molecule identified in C. elegans that mediates recognition of apoptotic cells by crosslinking the PtdSer 'eat me' signal with the phagocyte receptor CED-1.
Title: Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F11F1.6 (e-PCR)
- UniSTS:315711

F11F1.7 (e-PCR)
- UniSTS:315712

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables scavenger receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in aminophospholipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process involved in development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic process involved in development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in recognition of apoptotic cell	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Transthyretin-like protein 52

NP_001380125.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

13404718..13405783

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392229.1 → NP_001380125.1 Transthyretin-like protein 52 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ED35

Conserved Domains (1) summary

pfam01060
Location:28 → 114

TTR-52; Transthyretin-like family