tsp-14 Tetraspanin-14 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tsp-14
Official Full Name: Tetraspanin-14
Primary source: WormBase:WBGene00006640
Locus tag: CELE_F39C12.3
See related: AllianceGenome:WB:WBGene00006640
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protease binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of BMP signaling pathway; and positive regulation of egg-laying behavior. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and endosome membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including germ line; hypodermis; nose; sperm; and vulva. Used to study cancer. Orthologous to human TSPAN10 (tetraspanin 10). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tsp-14 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 9

Sequence:: Chromosome: X; NC_003284.9 (4866684..4874493, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function.
Title: The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function.
TSP-12 and TSP-14 are required for the recycling of DAF-4/BMPRII.
Title: Tetraspanins TSP-12 and TSP-14 function redundantly to regulate the trafficking of the type II BMP receptor in Caenorhabditis elegans.
TSP-12 and TSP-14 function redundantly to promote BMP signaling.
Title: Two Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F39C12.3 (e-PCR)
- UniSTS:313124

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in nematode male tail tip morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of egg-laying behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mesodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Tetraspanin-14

NP_001367834.1

Confirmed by transcript evidence

NP_001379941.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4866684..4874493 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392767.1 → NP_001379941.1 Tetraspanin-14 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

COG0841
Location:42 → 99

AcrB; Multidrug efflux pump subunit AcrB [Defense mechanisms]

cl02781
Location:121 → 262

tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
NM_001380953.1 → NP_001367834.1 Tetraspanin-14 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L006, O44582

Conserved Domains (2) summary

COG0841
Location:66 → 123

AcrB; Multidrug efflux pump subunit AcrB [Defense mechanisms]

cl02781
Location:145 → 286

tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...