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    slc-28.1 Concentrative nucleoside transporter C-terminal domain-containing protein;Sodium/nucleoside cotransporter [ Caenorhabditis elegans ]

    Gene ID: 178770, updated on 4-Jan-2025

    Summary

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    Official Symbol
    slc-28.1
    Official Full Name
    Concentrative nucleoside transporter C-terminal domain-containing protein;Sodium/nucleoside cotransporter
    Primary source
    WormBase:WBGene00017867
    Locus tag
    CELE_F27E11.1
    See related
    AllianceGenome:WB:WBGene00017867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nucleoside:sodium symporter activity. Predicted to be involved in nucleoside transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including SLC28A1 (solute carrier family 28 member 1) and SLC28A2 (solute carrier family 28 member 2). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See slc-28.1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (3463814..3466192)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Sodium/nucleoside cotransporter Neighboring gene ncRNA Neighboring gene Glutathione S-Transferase Neighboring gene Serpentine Receptor, class BC (Class B-like)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements. Maroilley T, et al. Genome Res, 2023 Jan. PMID 36617680, Free PMC Article
    2. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables nucleoside transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleoside transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Concentrative nucleoside transporter C-terminal domain-containing protein;Sodium/nucleoside cotransporter
    NP_001309638.1
    • Confirmed by transcript evidence
    NP_503967.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      3463814..3466192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071566.5 → NP_503967.1  Sodium/nucleoside cotransporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503967.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE77
      Conserved Domains (4) summary
      TIGR00804
      Location:141 → 547
      nupC; nucleoside transporter
      pfam01773
      Location:158 → 215
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:336 → 547
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:239 → 330
      Gate; Nucleoside recognition

    2. NM_001322519.1 → NP_001309638.1  Concentrative nucleoside transporter C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBN5
      Conserved Domains (1) summary
      pfam07662
      Location:1 → 89
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    Nucleotide Protein
    Heading Accession and Version

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