chc-1 putative clathrin heavy chain 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: chc-1
Official Full Name: putative clathrin heavy chain 1
Primary source: WormBase:WBGene00011867
Locus tag: CELE_T20G5.1
See related: AllianceGenome:WB:WBGene00011867
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable clathrin light chain binding activity. Involved in several processes, including apical protein localization; determination of adult lifespan; and positive regulation of clathrin-dependent endocytosis. Located in several cellular components, including apical plasma membrane; clathrin-coated endocytic vesicle; and mitotic spindle. Is expressed in coelomocyte; germ line; hypodermal cell; intestine; and pharyngeal cell. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain) and CLTCL1 (clathrin heavy chain like 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See chc-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (10203821..10209704)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The clathrin heavy chain CHC-1 negatively regulates pulling forces acting on centrosomes during interphase and on spindle poles during mitosis in one-cell C. elegans embryos.
Title: Clathrin regulates centrosome positioning by promoting acto-myosin cortical tension in C. elegans embryos.
Inactivating epn-1 or chc-1 disrupts engulfment by impairing actin polymerization. CHC-1 is enriched on extending pseudopods together with EPN-1, in an EPN-1-dependent manner.
Title: Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. elegans.
Loss of SNX-1, RME-8, or the clathrin chaperone Hsc70/HSP-1 leads to over-accumulation of endosomal clathrin, reduced clathrin dynamics, and missorting of MIG-14 to the lysosome.
Title: Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8.
These results indicate that a high level of CHC activity is required for receptor-mediated endocytosis in nonneuronal cells but is largely dispensable for maintenance of synaptic vesicle pools.
Title: Differential requirements for clathrin in receptor-mediated endocytosis and maintenance of synaptic vesicle pools.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T20G5.1 (e-PCR)
- UniSTS:308064

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables clathrin light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin light chain binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
part_of clathrin coat of coated pit	IEA Inferred from Electronic Annotation more info
part_of clathrin coat of trans-Golgi network vesicle	IEA Inferred from Electronic Annotation more info
part_of clathrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of clathrin complex	IEA Inferred from Electronic Annotation more info
is_active_in clathrin-coated endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in clathrin-coated endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: putative clathrin heavy chain 1

NP_499260.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10203821..10209704

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066859.5 → NP_499260.1 putative clathrin heavy chain 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499260.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34574

Conserved Domains (5) summary

smart00299
Location:1276 → 1418

CLH; Clathrin heavy chain repeat homology

pfam00637
Location:985 → 1121

Clathrin; Region in Clathrin and VPS

pfam01394
Location:196 → 232

Clathrin_propel; Clathrin propeller repeat

pfam09268
Location:329 → 351

Clathrin-link; Clathrin, heavy-chain linker

pfam13838
Location:362 → 419

Clathrin_H_link; Clathrin-H-link