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    gpx-5 Glutathione peroxidase [ Caenorhabditis elegans ]

    Gene ID: 181178, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpx-5
    Official Full Name
    Glutathione peroxidase
    Primary source
    WormBase:WBGene00007516
    Locus tag
    CELE_C11E4.1
    See related
    AllianceGenome:WB:WBGene00007516
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutathione peroxidase activity. Involved in response to reactive oxygen species. Predicted to be located in extracellular space. Is expressed in head; hypodermis; intestine; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cardiovascular system disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and respiratory system cancer (multiple). Orthologous to several human genes including GPX3 (glutathione peroxidase 3) and GPX5 (glutathione peroxidase 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpx-5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Sequence:
    Chromosome: X; NC_003284.9 (9584668..9586344)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Glutathione peroxidase 3 Neighboring gene ncRNA Neighboring gene DEgenerin Like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Circadian stress tolerance in adult Caenorhabditis elegans. Simonetta SH, et al. J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2008 Sep. PMID 18648821
    2. Deletion of the four phospholipid hydroperoxide glutathione peroxidase genes accelerates aging in Caenorhabditis elegans. Sakamoto T, et al. Genes Cells, 2014 Oct. PMID 25200408
    3. Copper ions influence the toxicity of β-amyloid(1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease. Luo Y, et al. Sci China Life Sci, 2011 Jun. PMID 21706413
    4. The glutathione reductase GSR-1 determines stress tolerance and longevity in Caenorhabditis elegans. Lüersen K, et al. PLoS One, 2013. PMID 23593298, Free PMC Article
    5. Specific collagens maintain the cuticle permeability barrier in Caenorhabditis elegans. Sandhu A, et al. Genetics, 2021 Mar 31. PMID 33789349, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to chemical IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Glutathione peroxidase
    NP_509615.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9584668..9586344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077214.6 → NP_509615.3  Glutathione peroxidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509615.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93204
      Conserved Domains (1) summary
      cd00340
      Location:39 → 203
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
    Nucleotide Protein
    Heading Accession and Version

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