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    tbb-1 Tubulin beta chain [ Caenorhabditis elegans ]

    Gene ID: 176501, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbb-1
    Official Full Name
    Tubulin beta chain
    Primary source
    WormBase:WBGene00006536
    Locus tag
    CELE_K01G5.7
    See related
    AllianceGenome:WB:WBGene00006536
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in spindle microtubule. Is expressed in several structures, including excretory gland cell; intestine; nervous system; pharynx; and uv1. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 6; congenital symmetric circumferential skin creases 1; hypomyelinating leukodystrophy 6; and torsion dystonia 4. Orthologous to human TUBB4A (tubulin beta 4A class IVa) and TUBB (tubulin beta class I). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tbb-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (10740868..10742432, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Arf-GAP domain-containing protein Neighboring gene Protein FAM32A Neighboring gene Exostosin-2 homolog Neighboring gene GTP-binding nuclear protein ran-1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maternally expressed and partially redundant beta-tubulins in Caenorhabditis elegans are autoregulated. Ellis GC, et al. J Cell Sci, 2004 Jan 26. PMID 14702387
    2. Motor neuron synapse and axon defects in a C. elegans alpha-tubulin mutant. Baran R, et al. PLoS One, 2010 Mar 11. PMID 20300184, Free PMC Article
    3. Mutations in a beta-tubulin disrupt spindle orientation and microtubule dynamics in the early Caenorhabditis elegans embryo. Wright AJ, et al. Mol Biol Cell, 2003 Nov. PMID 12937270, Free PMC Article
    4. The Caenorhabditis elegans microtubule-severing complex MEI-1/MEI-2 katanin interacts differently with two superficially redundant beta-tubulin isotypes. Lu C, et al. Mol Biol Cell, 2004 Jan. PMID 14565976, Free PMC Article
    5. Roles for two partially redundant alpha-tubulins during mitosis in early Caenorhabditis elegans embryos. Phillips JB, et al. Cell Motil Cytoskeleton, 2004 Jun. PMID 15083533

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tubulin beta chain
    NP_499367.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10740868..10742432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066966.9 → NP_499367.1  Tubulin beta chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499367.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17921
      Conserved Domains (2) summary
      PLN00220
      Location:1 → 447
      PLN00220; tubulin beta chain; Provisional
      cd02187
      Location:2 → 426
      beta_tubulin; The beta-tubulin family
    Nucleotide Protein
    Heading Accession and Version

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