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    pfs-2 pre-mRNA 3' end processing protein pfs-2 [ Caenorhabditis elegans ]

    Gene ID: 175092, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pfs-2
    Official Full Name
    pre-mRNA 3' end processing protein pfs-2
    Primary source
    WormBase:WBGene00011051
    Locus tag
    CELE_R06A4.9
    See related
    AllianceGenome:WB:WBGene00011051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mRNA 3'-end processing. Located in nuclear speck. Orthologous to human WDR33 (WD repeat domain 33). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pfs-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (14358366..14361684)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Protein lin-7 homolog Neighboring gene L51_S25_CI-B8 domain-containing protein Neighboring gene Transcription elongation factor 1 homolog Neighboring gene Glycogen debranching enzyme Neighboring gene SPK domain-containing protein Neighboring gene Importin N-terminal domain-containing protein Neighboring gene AcetylCholine Receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans 3' UTRome v2 resource for studying mRNA cleavage and polyadenylation, 3'-UTR biology, and miRNA targeting. Steber HS, et al. Genome Res, 2019 Dec. PMID 31744903, Free PMC Article
    2. Nuclear pre-mRNA 3'-end processing regulates synapse and axon development in C. elegans. Van Epps H, et al. Development, 2010 Jul. PMID 20530551, Free PMC Article
    3. Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans. Ham S, et al. Genome Res, 2022 Nov-Dec. PMID 36351769, Free PMC Article
    4. Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin. LaBella ML, et al. Dev Cell, 2020 Jan 6. PMID 31910362, Free PMC Article
    5. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Wang W, et al. Traffic, 2008 May. PMID 18298590, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pre-mRNA 3' end processing protein pfs-2
    NP_001368351.1
    • Confirmed by transcript evidence
    NP_001379014.1
    • Confirmed by transcript evidence
    NP_001380152.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14358366..14361684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393231.1 → NP_001380152.1  pre-mRNA 3' end processing protein pfs-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A5S9MNP8, U4PCM1, U4PN22
      Conserved Domains (2) summary
      cd00200
      Location:135 → 417
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:136 → 173
      7WD40; WD40 repeat [structural motif]

    2. NM_001393232.1 → NP_001379014.1  pre-mRNA 3' end processing protein pfs-2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      smart00320
      Location:135 → 161
      WD40; WD40 repeats
      sd00039
      Location:137 → 172
      7WD40; WD40 repeat [structural motif]

    3. NM_001381653.1 → NP_001368351.1  pre-mRNA 3' end processing protein pfs-2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd00200
      Location:5 → 212
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:16 → 52
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    U4PCM1.2

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