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    • Showing Current items.

    kgb-2 Stress-activated protein kinase JNK [ Caenorhabditis elegans ]

    Gene ID: 191169, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kgb-2
    Official Full Name
    Stress-activated protein kinase JNK
    Primary source
    WormBase:WBGene00002188
    Locus tag
    CELE_ZC416.4
    See related
    AllianceGenome:WB:WBGene00002188
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable JUN kinase activity. Predicted to be involved in JNK cascade. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kgb-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (3606784..3609229)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene BRCT domain-containing protein Neighboring gene Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein Neighboring gene Choline O-acetyltransferase Neighboring gene Vesicular acetylcholine transporter unc-17 Neighboring gene Cysteine-rich transmembrane CYSTM domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Triphenyl phosphate induced reproductive toxicity through the JNK signaling pathway in Caenorhabditis elegans. Shi C, et al. J Hazard Mater, 2023 Mar 15. PMID 36586333
    2. Intrinsic JNK-MAPK pathway involvement requires daf-16-mediated immune response during Shigella flexneri infection in C. elegans. Marudhupandiyan S, et al. Immunol Res, 2017 Jun. PMID 27838822
    3. Evolutionary conserved role of c-Jun-N-terminal kinase in CO2-induced epithelial dysfunction. Vadász I, et al. PLoS One, 2012. PMID 23056407, Free PMC Article
    4. MAPping innate immunity. Young JA, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15328410, Free PMC Article
    5. The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response. Mizuno T, et al. EMBO J, 2004 Jun 2. PMID 15116070, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. responsible for the immune response elicited by the host during the Shigella flexneri infection
      Title: Intrinsic JNK-MAPK pathway involvement requires daf-16-mediated immune response during Shigella flexneri infection in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Stress-activated protein kinase JNK
    NP_500384.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3606784..3609229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067983.4 → NP_500384.2  Stress-activated protein kinase JNK [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500384.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZI0
      Conserved Domains (2) summary
      smart00220
      Location:29 → 326
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:28 → 329
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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