Y17G7B.12 RNA exonuclease 4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: Y17G7B.12
Official Full Name: RNA exonuclease 4
Primary source: WormBase:WBGene00012465
Locus tag: CELE_Y17G7B.12
See related: AllianceGenome:WB:WBGene00012465
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable exonuclease activity. Predicted to be involved in DNA catabolic process and RNA processing. Predicted to be active in nucleus. Orthologous to several human genes including REXO4 (REX4 homolog, 3'-5' exonuclease). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See Y17G7B.12 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (12023861..12025913)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y17G7B.12 (e-PCR)
- UniSTS:322377

Y17G7B.6 (e-PCR)
- UniSTS:318647

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA exonuclease 4

NP_496560.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

12023861..12025913

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064159.6 → NP_496560.1 RNA exonuclease 4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496560.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XXI3

Conserved Domains (1) summary

cd06144
Location:103 → 254

REX4_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product of 20 kDa, and similar proteins