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    mut-14 RNA helicase [ Caenorhabditis elegans ]

    Gene ID: 178952, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mut-14
    Official Full Name
    RNA helicase
    Primary source
    WormBase:WBGene00003507
    Locus tag
    CELE_C14C11.6
    See related
    AllianceGenome:WB:WBGene00003507
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA helicase activity and mRNA binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Located in mutator focus. Is expressed in germ cell and germ line. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mut-14 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (5658713..5660704, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CUB-like domain-containing protein Neighboring gene beta-N-acetylhexosaminidase Neighboring gene YDG domain-containing protein Neighboring gene Movement protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Low impact of germline transposition on the rate of mildly deleterious mutation in Caenorhabditis elegans. Bégin M, et al. Genetics, 2006 Dec. PMID 17057249, Free PMC Article
    2. Transposable elements, mutational correlations, and population divergence in Caenorhabditis elegans. Bégin M, et al. Evolution, 2007 May. PMID 17492961
    3. RNAi protects the Caenorhabditis elegans germline against transposition. Vastenhouw NL, et al. Trends Genet, 2004 Jul. PMID 15219396
    4. mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Zhang C, et al. Proc Natl Acad Sci U S A, 2011 Jan 25. PMID 21245313, Free PMC Article
    5. Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi. Sijen T, et al. Nature, 2003 Nov 20. PMID 14628056

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation.
      Title: MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamete generation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mutator focus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA helicase
    NP_504490.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5658713..5660704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072089.6 → NP_504490.1  RNA helicase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504490.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17978
      Conserved Domains (3) summary
      COG0513
      Location:101 → 523
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00270
      Location:117 → 297
      DEAD; DEAD/DEAH box helicase
      pfam00271
      Location:352 → 471
      Helicase_C; Helicase conserved C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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