smd-1 S-adenosylmethionine decarboxylase beta chain [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: smd-1
Official Full Name: S-adenosylmethionine decarboxylase beta chain
Primary source: WormBase:WBGene00004875
Locus tag: CELE_F47G4.7
See related: AllianceGenome:WB:WBGene00004875
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables adenosylmethionine decarboxylase activity. Involved in spermidine biosynthetic process and spermine biosynthetic process. Predicted to be active in cytosol. Is expressed in intestine and neurons. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See smd-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (14048101..14051003, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F47G4.7 (e-PCR)
- UniSTS:312603

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables adenosylmethionine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosylmethionine decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenosylmethionine decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in spermidine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermidine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in spermidine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in spermine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in spermine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: S-adenosylmethionine decarboxylase beta chain

NP_001379243.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14048101..14051003 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392971.1 → NP_001379243.1 S-adenosylmethionine decarboxylase beta chain [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O02655

Conserved Domains (1) summary

TIGR00535
Location:25 → 350

SAM_DCase; S-adenosylmethionine decarboxylase proenzyme, eukaryotic form