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    hus-1 Checkpoint protein [ Caenorhabditis elegans ]

    Gene ID: 171939, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hus-1
    Official Full Name
    Checkpoint protein
    Primary source
    WormBase:WBGene00002042
    Locus tag
    CELE_H26D21.1
    See related
    AllianceGenome:WB:WBGene00002042
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including DNA metabolic process; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage. Located in chromatin and germ cell nucleus. Is expressed in germ line. Orthologous to several human genes including HUS1B (HUS1 checkpoint clamp component B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hus-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (3698102..3699300)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DNA mismatch repair proteins mutS family domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects induced by keV low-energy ion irradiation in the nematode Caenorhabditis elegans. Liu X, et al. Radiat Environ Biophys, 2007 Aug. PMID 17380344
    2. Synergistic effects induced by a low dose of diesel particulate extract and ultraviolet-A in Caenorhabditis elegans: DNA damage-triggered germ cell apoptosis. Guo X, et al. Chem Res Toxicol, 2014 Jun 16. PMID 24841043, Free PMC Article
    3. Nickel-induced apoptosis and relevant signal transduction pathways in Caenorhabditis elegans. Cai Kezhou, et al. Toxicol Ind Health, 2010 May. PMID 20237193
    4. Interaction between Radioadaptive Response and Radiation-Induced Bystander Effect in Caenorhabditis elegans : A Unique Role of the DNA Damage Checkpoint. Tang H, et al. Radiat Res, 2016 Dec. PMID 27874324
    5. Reproductive toxicity by exposure to low concentrations of pesticides in Caenorhabditis elegans. Moya A, et al. Toxicology, 2022 Jun 15. PMID 35697162

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA damage checkpoint protein hus-1 suppresses the frequency of mutation by ensuring that spontaneous DNA damage is accurately repaired in C. elegans germ cells.
      Title: Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants.
    2. required for DNA damage-induced cell cycle arrest and apoptosis
      Title: Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA integrity checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of checkpoint clamp complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of checkpoint clamp complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Checkpoint protein
    NP_491203.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3698102..3699300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058802.7 → NP_491203.1  Checkpoint protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491203.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFI9
      Conserved Domains (1) summary
      pfam04005
      Location:1 → 272
      Hus1; Hus1-like protein
    Nucleotide Protein
    Heading Accession and Version

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