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    wrt-6 Warthog protein 6 N-product [ Caenorhabditis elegans ]

    Gene ID: 180638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wrt-6
    Official Full Name
    Warthog protein 6 N-product
    Primary source
    WormBase:WBGene00006952
    Locus tag
    CELE_ZK377.1
    See related
    AllianceGenome:WB:WBGene00006952
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in cell-cell signaling; protein autoprocessing; and system development. Predicted to be located in cell surface; extracellular region; and plasma membrane. Predicted to be active in extracellular matrix. Is expressed in anterior ganglion (ant); hypodermis; and neuronal sheath cell. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and solitary median maxillary central incisor. Orthologous to human SHH (sonic hedgehog signaling molecule). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See wrt-6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (3480250..3483666)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New deletion alleles for Caenorhabditis elegans Hedgehog pathway-related genes wrt-6 and wrt-10. Sherry T, et al. MicroPubl Biol, 2019 Oct 15. PMID 32550467, Free PMC Article
    2. Impairing one sensory modality enhances another by reconfiguring peptidergic signalling in Caenorhabditis elegans. Valperga G, et al. Elife, 2022 Feb 24. PMID 35201977, Free PMC Article
    3. Warthog and groundhog, novel families related to hedgehog. Bürglin TR. Curr Biol, 1996 Sep 1. PMID 8805384
    4. Homologs of the Hh signalling network in C. elegans. Bürglin TR, et al. WormBook, 2006 Jan 28. PMID 18050469, Free PMC Article
    5. New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans. Abete-Luzi P, et al. Genetics, 2020 Mar. PMID 31974205, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Warthog protein 6 N-product
    NP_508597.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3480250..3483666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076196.7 → NP_508597.2  Warthog protein 6 N-product [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508597.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91573, Q9U7D2
      Conserved Domains (2) summary
      smart00306
      Location:394 → 492
      HintN; Hint (Hedgehog/Intein) domain N-terminal region
      pfam01079
      Location:389 → 583
      Hint; Hint module
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91573.2

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