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    ins-35 INSulin related [ Caenorhabditis elegans ]

    Gene ID: 180334, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ins-35
    Official Full Name
    INSulin related
    Primary source
    WormBase:WBGene00002118
    Locus tag
    CELE_K02E2.4
    See related
    AllianceGenome:WB:WBGene00002118
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable insulin receptor binding activity. Involved in insulin receptor signaling pathway and negative regulation of dauer larval development. Located in extracellular space. Is expressed in intestine; neurons; rectum; and ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ins-35 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (20375536..20376302)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Peptidase A2 domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diapause is associated with a change in the polarity of secretion of insulin-like peptides. Matsunaga Y, et al. Nat Commun, 2016 Feb 3. PMID 26838180, Free PMC Article
    2. Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling. Neal SJ, et al. Elife, 2015 Sep 3. PMID 26335407, Free PMC Article
    3. The G protein-coupled receptor neuropeptide receptor-15 modulates larval development via the transforming growth factor-β DAF-7 protein in Caenorhabditis elegans. Ono M, et al. Biochem Biophys Res Commun, 2023 Jun 11. PMID 37060828
    4. Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans. Honda Y, et al. Sci Rep, 2012. PMID 22768380, Free PMC Article
    5. Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest. Chen Y, et al. Dev Biol, 2014 Oct 15. PMID 25128585

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables insulin receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    INSulin related
    NP_507926.1
    • Product from WormBase gene class ins;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20375536..20376302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075525.5 → NP_507926.1  INSulin related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507926.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUV3
    Nucleotide Protein
    Heading Accession and Version

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