fat-3 Delta(6)-fatty-acid desaturase fat-3;Fatty acid desaturase domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fat-3
Official Full Name: Delta(6)-fatty-acid desaturase fat-3;Fatty acid desaturase domain-containing protein
Primary source: WormBase:WBGene00001395
Locus tag: CELE_W08D2.4
See related: AllianceGenome:WB:WBGene00001395
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables stearoyl-CoA 9-desaturase activity. Involved in several processes, including egg-laying behavior; nematode pharyngeal pumping; and signal release. Predicted to be located in membrane. Is expressed in body wall musculature; head neurons; intestine; pharynx; and tail neurons. Used to study alcohol use disorder and lipid metabolism disorder. Orthologous to several human genes including FADS2 (fatty acid desaturase 2) and FADS3 (fatty acid desaturase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fat-3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (9803023..9806119)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Juniperonic Acid Biosynthesis is Essential in Caenorhabditis Elegans Lacking Delta6 Desaturase (fat-3) and Generates New omega-3 Endocannabinoids.
Title: Juniperonic Acid Biosynthesis is Essential in Caenorhabditis Elegans Lacking Δ6 Desaturase (fat-3) and Generates New ω-3 Endocannabinoids.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W08D2.4 (e-PCR)
- UniSTS:308162

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables linoleoyl-CoA desaturase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IBA Inferred from Biological aspect of Ancestor more info
enables stearoyl-CoA 9-desaturase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in acetylcholine secretion, neurotransmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collagen and cuticulin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in unsaturated fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in unsaturated fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IC Inferred by Curator more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Delta(6)-fatty-acid desaturase fat-3;Fatty acid desaturase domain-containing protein

NP_001255426.1

Confirmed by transcript evidence

NP_001255427.1

Confirmed by transcript evidence

NP_001255428.1

Confirmed by transcript evidence

NP_001294085.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9803023..9806119

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268497.2 → NP_001255426.1 Delta(6)-fatty-acid desaturase fat-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255426.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E9P867, E9P868, O61388, Q23221

Conserved Domains (3) summary

cd03506
Location:150 → 413

Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...

pfam00487
Location:148 → 415

FA_desaturase; Fatty acid desaturase

cl09111
Location:52 → 113

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
NM_001307156.3 → NP_001294085.1 Fatty acid desaturase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294085.1

Status: REVIEWED

UniProtKB/TrEMBL

N1NTM6

Conserved Domains (1) summary

cd03506
Location:49 → 312

Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...
NM_001268498.3 → NP_001255427.1 Delta(6)-fatty-acid desaturase fat-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255427.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23221

Conserved Domains (1) summary

cd03506
Location:32 → 155

Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...
NM_001268499.3 → NP_001255428.1 Delta(6)-fatty-acid desaturase fat-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255428.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23221

Conserved Domains (2) summary

pfam03192
Location:40 → 68

DUF257; Pyrococcus protein of unknown function, DUF257

cl00615
Location:1 → 47

Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...