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    pad-1 Protein pad-1 [ Caenorhabditis elegans ]

    Gene ID: 173156, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pad-1
    Official Full Name
    Protein pad-1
    Primary source
    WormBase:WBGene00003905
    Locus tag
    CELE_Y18D10A.13
    See related
    AllianceGenome:WB:WBGene00003905
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in Golgi to endosome transport and protein transport. Predicted to be located in cytosol. Predicted to be active in endosome and trans-Golgi network. Is expressed in several structures, including anal depressor muscle; excretory cell; intestine; nervous system; and reproductive system. Used to study Down syndrome. Orthologous to human DOP1A (DOP1 leucine zipper like protein A) and DOP1B (DOP1 leucine zipper like protein B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pad-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    23
    Sequence:
    Chromosome: I; NC_003279.8 (12878639..12902806)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Amino acid transporter transmembrane domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene Cytochrome c oxidase assembly factor 5 Neighboring gene Protein LSM14 homolog car-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved N- and C-terminal motifs of PAD-1 are required to inhibit extracellular vesicle release. Pitts LR, et al. MicroPubl Biol, 2022. PMID 36188098, Free PMC Article
    2. C21orf5, a novel human chromosome 21 gene, has a Caenorhabditis elegans ortholog (pad-1) required for embryonic patterning. Guipponi M, et al. Genomics, 2000 Aug 15. PMID 10950924
    3. Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans. Pascon RC, et al. Mol Microbiol, 2000 Jun. PMID 10931277
    4. MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications. Artan M, et al. Autophagy, 2022 May. PMID 35188063, Free PMC Article
    5. Loss of the Major Phosphatidylserine or Phosphatidylethanolamine Flippases Differentially Affect Phagocytosis. Fazeli G, et al. Front Cell Dev Biol, 2020. PMID 32793595, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein pad-1
    NP_493252.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12878639..12902806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060851.7 → NP_493252.3  Protein pad-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493252.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U5Z2, Q9XW10
      Conserved Domains (2) summary
      pfam04118
      Location:18 → 300
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2053 → 2373
      Dopey_N; Dopey, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XW10.2

    Gene LinkOut

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