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    tmem-107 Transmembrane protein 107 [ Caenorhabditis elegans ]

    Gene ID: 13183089, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tmem-107
    Official Full Name
    Transmembrane protein 107
    Primary source
    WormBase:WBGene00043308
    Locus tag
    CELE_F39B2.9
    See related
    AllianceGenome:WB:WBGene00043308
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in dendrite development; non-motile cilium assembly; and protein localization to ciliary transition zone. Located in ciliary transition zone. Is expressed in ciliated neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tmem-107 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003279.8 (14758776..14759473, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene F-box/LRR-repeat protein Neighboring gene Metaxin-1 homolog Neighboring gene DNaJ domain (prokaryotic heat shock protein) Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein eS26 Neighboring gene G-protein coupled receptors family 3 profile domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Forkhead transcription factor FKH-8 cooperates with RFX in the direct regulation of sensory cilia in Caenorhabditis elegans. Brocal-Ruiz R, et al. Elife, 2023 Jul 14. PMID 37449480, Free PMC Article
    2. WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing. De-Castro ARG, et al. J Cell Biol, 2022 Jan 3. PMID 34739033, Free PMC Article
    3. The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate. Gonçalves J, et al. Mol Cells, 2017 Apr. PMID 28401750, Free PMC Article
    4. TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome. Lambacher NJ, et al. Nat Cell Biol, 2016 Jan. PMID 26595381, Free PMC Article
    5. The C. elegans regulatory factor X (RFX) DAF-19M module: A shift from general ciliogenesis to cell-specific ciliary and behavioral specialization. Ahn S, et al. Cell Rep, 2022 Apr 12. PMID 35417689

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in dendrite development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-motile cilium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to ciliary transition zone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MKS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transmembrane protein 107
    NP_001252431.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14758776..14759473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001265502.3 → NP_001252431.1  Transmembrane protein 107 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001252431.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L2K0
      Conserved Domains (1) summary
      pfam14995
      Location:12 → 124
      TMEM107; Transmembrane protein
    Nucleotide Protein
    Heading Accession and Version

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