F09E5.8 Pyridoxal phosphate homeostasis protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F09E5.8
Official Full Name: Pyridoxal phosphate homeostasis protein
Primary source: WormBase:WBGene00017286
Locus tag: CELE_F09E5.8
See related: AllianceGenome:WB:WBGene00017286
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable pyridoxal phosphate binding activity. Human ortholog(s) of this gene implicated in early-onset vitamin B6-dependent epilepsy 1. Orthologous to human PLPBP (pyridoxal phosphate binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See F09E5.8 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (5350669..5351993)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS2-139 (e-PCR)
- UniSTS:241806

F09E5.8 (e-PCR)
- UniSTS:322044

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in vitamin B6 metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Pyridoxal phosphate homeostasis protein

NP_495001.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5350669..5351993

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062600.6 → NP_495001.1 Pyridoxal phosphate homeostasis protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495001.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P52057

Conserved Domains (1) summary

cd06822
Location:6 → 237

PLPDE_III_YBL036c_euk; Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Eukaryotic YBL036c-like proteins