ufd-2 Ubiquitin conjugation factor E4 ufd-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ufd-2
Official Full Name: Ubiquitin conjugation factor E4 ufd-2
Primary source: WormBase:WBGene00006734
Locus tag: CELE_T05H10.5
See related: AllianceGenome:WB:WBGene00006734
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein-folding chaperone binding activity; ubiquitin protein ligase binding activity; and ubiquitin-ubiquitin ligase activity. Involved in determination of adult lifespan; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein ubiquitination. Located in cytoplasm and nucleus. Is expressed in body wall musculature; hypodermis; neurons; and pharyngeal muscle cell. Orthologous to human UBE4B (ubiquitination factor E4B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ufd-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (8062741..8066193)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans.
Title: The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans.
UFD-2 and UFD-3 bind to CDC-48 in a mutually exclusive manner.CDC-48 preferentially interacts with UFD-3 in C. elegans under the physiological condition.
Title: Characterization of C-terminal adaptors, UFD-2 and UFD-3, of CDC-48 on the polyglutamine aggregation in C. elegans.
UFD-2 is not regulating the protein levels of UNC-45 in muscle cells, but rather shows the characteristic properties of a bona fide E3 ligase involved in protein quality control. UFD-2 preferentially targets unfolded protein segments.
Title: UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins.
Ligase activity of UFD-2 triggers DNA double-strand breaks -induced apoptosis. UFD-2 supports RAD-51 dissociation from DNA-repair sites.
Title: E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T05H10.5 (e-PCR)
- UniSTS:310686

T05H10.6 (e-PCR)
- UniSTS:310687

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-ubiquitin ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-ubiquitin ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-ubiquitin ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein K29-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ubiquitin conjugation factor E4 ufd-2

NP_001022320.1

Confirmed by transcript evidence

NP_001369867.1

Confirmed by transcript evidence

NP_495691.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8062741..8066193

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063290.3 → NP_495691.1 Ubiquitin conjugation factor E4 ufd-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495691.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09349, Q6BEV4, Q95QB5

Conserved Domains (2) summary

pfam10408
Location:283 → 893

Ufd2P_core; Ubiquitin elongating factor core

cd16658
Location:906 → 980

RING-Ubox_UBE4B; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 B (UBE4B) and similar proteins
NM_001027149.5 → NP_001022320.1 Ubiquitin conjugation factor E4 ufd-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022320.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6BEV4

Conserved Domains (2) summary

pfam04564
Location:905 → 976

U-box; U-box domain

pfam10408
Location:279 → 888

Ufd2P_core; Ubiquitin elongating factor core
NM_001383900.2 → NP_001369867.1 Ubiquitin conjugation factor E4 ufd-2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd16658
Location:902 → 976

RING-Ubox_UBE4B; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 B (UBE4B) and similar proteins

pfam10408
Location:279 → 889

Ufd2P_core; Ubiquitin elongating factor core