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    mig-22 Chondroitin sulfate synthase mig-22 [ Caenorhabditis elegans ]

    Gene ID: 176231, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mig-22
    Official Full Name
    Chondroitin sulfate synthase mig-22
    Primary source
    WormBase:WBGene00003253
    Locus tag
    CELE_PAR2.4
    See related
    AllianceGenome:WB:WBGene00003253
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables enzyme binding activity. Predicted to be involved in chondroitin sulfate biosynthetic process. Predicted to be located in Golgi cisterna membrane. Is expressed in hermaphrodite distal tip cell; oocyte; pharynx; seam cell; and vulva. Orthologous to human CHPF (chondroitin polymerizing factor) and CHPF2 (chondroitin polymerizing factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mig-22 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (8763538..8767341, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Dwarfin sma-2;MH2 domain-containing protein Neighboring gene ncRNA Neighboring gene 5'-AMP-activated protein kinase catalytic subunit alpha-1 Neighboring gene Single-stranded DNA-binding protein, mitochondrial Neighboring gene Glycerol-3-phosphate phosphatase;Putative NipSnap protein K02D10.1 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nematode chondroitin polymerizing factor showing cell-/organ-specific expression is indispensable for chondroitin synthesis and embryonic cell division. Izumikawa T, et al. J Biol Chem, 2004 Dec 17. PMID 15485872
    2. Endogenous chondroitin extends the lifespan and healthspan in C. elegans. Shibata Y, et al. Sci Rep, 2024 Feb 27. PMID 38413743, Free PMC Article
    3. Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis. Kitagawa H, et al. J Biol Chem, 2007 Mar 16. PMID 17237233
    4. Chondroitin acts in the guidance of gonadal distal tip cells in C. elegans. Suzuki N, et al. Dev Biol, 2006 Dec 15. PMID 16982046
    5. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondroitin sulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Chondroitin sulfate synthase mig-22
    NP_001360092.1
    • Confirmed by transcript evidence
    NP_498934.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8763538..8767341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001372637.3 → NP_001360092.1  Chondroitin sulfate synthase mig-22 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam05679
      Location:43 → 598
      CHGN; Chondroitin N-acetylgalactosaminyltransferase

    2. NM_066533.7 → NP_498934.1  Chondroitin sulfate synthase mig-22 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498934.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P45895, Q5NUN9, Q8IG00
      Conserved Domains (1) summary
      pfam05679
      Location:241 → 796
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45895.1

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