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    mtss-1 Single-stranded DNA-binding protein, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 187502, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mtss-1
    Official Full Name
    Single-stranded DNA-binding protein, mitochondrial
    Primary source
    WormBase:WBGene00019800
    Locus tag
    CELE_PAR2.1
    See related
    AllianceGenome:WB:WBGene00019800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to be involved in mitochondrial DNA replication and positive regulation of helicase activity. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial nucleoid. Is expressed in several structures, including body wall musculature; head; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in optic atrophy. Orthologous to human SSBP1 (single stranded DNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mtss-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (8768311..8769255)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Dwarfin sma-2;MH2 domain-containing protein Neighboring gene 5'-AMP-activated protein kinase catalytic subunit alpha-1 Neighboring gene Chondroitin sulfate synthase mig-22 Neighboring gene Glycerol-3-phosphate phosphatase;Putative NipSnap protein K02D10.1 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans. Moll L, et al. Elife, 2018 Nov 7. PMID 30403374, Free PMC Article
    2. The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline. Wang SY, et al. PLoS Genet, 2019 Jul. PMID 31283754, Free PMC Article
    3. Hypoxia-induced mitochondrial stress granules. Sun CL, et al. Cell Death Dis, 2023 Jul 19. PMID 37468471, Free PMC Article
    4. Caenorhabditis elegans par2.1/mtssb-1 is essential for mitochondrial DNA replication and its defect causes comprehensive transcriptional alterations including a hypoxia response. Sugimoto T, et al. Exp Cell Res, 2008 Jan 1. PMID 17900564
    5. DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Lin XX, et al. Nat Commun, 2018 Oct 23. PMID 30353013, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial genome maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial nucleoid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Single-stranded DNA-binding protein, mitochondrial
    NP_498935.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8768311..8769255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066534.5 → NP_498935.1  Single-stranded DNA-binding protein, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498935.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34496
      Conserved Domains (2) summary
      COG0629
      Location:53 → 170
      Ssb; Single-stranded DNA-binding protein [Replication, recombination and repair]
      pfam00436
      Location:54 → 159
      SSB; Single-strand binding protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34496.2

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