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    • Showing Current items.

    eipr-1 EARP-interacting protein 1 [ Caenorhabditis elegans ]

    Gene ID: 190778, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eipr-1
    Official Full Name
    EARP-interacting protein 1
    Primary source
    WormBase:WBGene00013599
    Locus tag
    CELE_Y87G2A.11
    See related
    AllianceGenome:WB:WBGene00013599
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in positive regulation of dense core granule transport; positive regulation of egg-laying behavior; and positive regulation of locomotion involved in locomotory behavior. Predicted to be located in cytoplasm. Orthologous to human EIPR1 (EARP complex and GARP complex interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eipr-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (13589178..13598505, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Ubiquitin-conjugating enzyme E2 S Neighboring gene Vacuolar protein sorting-associated protein 28 homolog Neighboring gene Lysosomal cobalamin transporter Neighboring gene SEC7 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells. Topalidou I, et al. Mol Biol Cell, 2020 Jan 1. PMID 31721635, Free PMC Article
    2. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, et al. PLoS Genet, 2016 May. PMID 27191843, Free PMC Article
    3. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells.
      Title: EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in positive regulation of dense core granule transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of dense core granule transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of egg-laying behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of locomotion involved in locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    EARP-interacting protein 1
    NP_493383.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13589178..13598505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060982.6 → NP_493383.1  EARP-interacting protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493383.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U1Q0
      Conserved Domains (3) summary
      COG2319
      Location:58 → 356
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:68 → 114
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:55 → 348
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U1Q0.1

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