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    tmem-189 Lipid desaturase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173080, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tmem-189
    Official Full Name
    Lipid desaturase domain-containing protein
    Primary source
    WormBase:WBGene00013136
    Locus tag
    CELE_Y53C10A.5
    See related
    AllianceGenome:WB:WBGene00013136
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable plasmanylethanolamine desaturase activity. Predicted to be involved in ether lipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in hypodermis; intestine; nervous system; and reproductive system. Orthologous to human PEDS1-UBE2V1 (PEDS1-UBE2V1 readthrough) and PEDS1 (plasmanylethanolamine desaturase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tmem-189 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (11998781..12002612)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Rho GTPase-activating protein 20 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ether lipid deficiency disrupts lipid homeostasis leading to ferroptosis sensitivity. Perez MA, et al. PLoS Genet, 2022 Sep. PMID 36178986, Free PMC Article
    2. A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis. Gallego-García A, et al. Science, 2019 Oct 4. PMID 31604315
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables plasmanylethanolamine desaturase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ether lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lipid desaturase domain-containing protein
    NP_493036.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      11998781..12002612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060635.9 → NP_493036.1  Lipid desaturase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493036.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XW52
      Conserved Domains (1) summary
      pfam10520
      Location:134 → 310
      TMEM189_B_dmain; B domain of TMEM189, localization domain
    Nucleotide Protein
    Heading Accession and Version

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