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    fog-2 F-box domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180321, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fog-2
    Official Full Name
    F-box domain-containing protein
    Primary source
    WormBase:WBGene00001482
    Locus tag
    CELE_Y113G7B.5
    See related
    AllianceGenome:WB:WBGene00001482
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including cytoplasmic streaming; hermaphrodite germ-line sex determination; and positive regulation of cell differentiation. Located in cytoplasm. Is expressed in germ line. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fog-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (20199254..20200648)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene F-box domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene F-box associated domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High parasite virulence necessary for the maintenance of host outcrossing via parasite-mediated selection. Slowinski SP, et al. Evol Lett, 2023 Dec. PMID 38045726, Free PMC Article
    2. The Caenorhabditis elegans Female-Like State: Decoupling the Transcriptomic Effects of Aging and Sperm Status. Angeles-Albores D, et al. G3 (Bethesda), 2017 Sep 7. PMID 28751504, Free PMC Article
    3. No detectable changes in reproductive behaviour of Caenorhabditis elegans males after 97 generations under obligatory outcrossing. Antoł W, et al. PeerJ, 2023. PMID 36643640, Free PMC Article
    4. Selection and maintenance of androdioecy in Caenorhabditis elegans. Stewart AD, et al. Genetics, 2002 Mar. PMID 11901115, Free PMC Article
    5. No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8. Keaney M, et al. Free Radic Biol Med, 2003 Jan 15. PMID 12521609

    See all (119) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest the female germline-specific tumor suppressor gld-1 (GLD-1)-feminization Of Germline FOG-2 protein (FOG-2) complex regulates uncharacterized sites within tra-2, or other mRNA targets.
      Title: Multi-modal regulation of C. elegans hermaphrodite spermatogenesis by the GLD-1-FOG-2 complex.
    2. Aamino acid replacement substitutions and gene conversion in fog-2 may contribute significantly to variation in the degree of inbreeding and outcrossing in natural populations.
      Title: Gene conversion and DNA sequence polymorphism in the sex-determination gene fog-2 and its paralog ftr-1 in Caenorhabditis elegans.
    3. regulation of the hermaphrodite germline sex determination pathway at the level of FOG-2/GLD-1/tra-2 mRNA is fundamentally different between C. elegans and C. briggsae
      Title: fog-2 and the evolution of self-fertile hermaphroditism in Caenorhabditis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation repressor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic streaming IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hermaphrodite germ-line sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box domain-containing protein
    NP_001041186.1
    • Partially confirmed by transcript evidence
    NP_001041187.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20199254..20200648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047721.4 → NP_001041186.1  F-box domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041186.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBU7, G5EEX5, G5EEZ2
      Conserved Domains (2) summary
      smart00256
      Location:23 → 63
      FBOX; A Receptor for Ubiquitination Targets
      pfam01827
      Location:143 → 283
      FTH; FTH domain

    2. NM_001047722.2 → NP_001041187.1  F-box domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041187.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBU7, G5EEZ2, Q2YS43
      Conserved Domains (2) summary
      smart00256
      Location:23 → 63
      FBOX; A Receptor for Ubiquitination Targets
      pfam01827
      Location:143 → 283
      FTH; FTH domain
    Nucleotide Protein
    Heading Accession and Version

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