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    smc-3 Structural maintenance of chromosomes protein 3 [ Caenorhabditis elegans ]

    Gene ID: 176559, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smc-3
    Official Full Name
    Structural maintenance of chromosomes protein 3
    Primary source
    WormBase:WBGene00004873
    Locus tag
    CELE_Y47D3A.26
    See related
    AllianceGenome:WB:WBGene00004873
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable double-stranded DNA binding activity. Predicted to be involved in mitotic sister chromatid cohesion. Located in chromatin. Part of cohesin complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3; hepatocellular carcinoma; and intellectual disability. Orthologous to human SMC3 (structural maintenance of chromosomes 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See smc-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    19
    Sequence:
    Chromosome: III; NC_003281.10 (11290904..11306247)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Density-regulated protein homolog Neighboring gene putative N-acetylgalactosaminyltransferase 9 Neighboring gene RING-type domain-containing protein Neighboring gene Ras-related protein Rab-35 Neighboring gene GYF domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Shugoshin Is Essential for Meiotic Prophase Checkpoints in C. elegans. Bohr T, et al. Curr Biol, 2018 Oct 22. PMID 30293721, Free PMC Article
    2. A new thermosensitive smc-3 allele reveals involvement of cohesin in homologous recombination in C. elegans. Baudrimont A, et al. PLoS One, 2011. PMID 21957461, Free PMC Article
    3. SUMOylation is essential for sex-specific assembly and function of the Caenorhabditis elegans dosage compensation complex on X chromosomes. Pferdehirt RR, et al. Proc Natl Acad Sci U S A, 2013 Oct 1. PMID 24043781, Free PMC Article
    4. Chromosome cohesion is regulated by a clock gene paralogue TIM-1. Chan RC, et al. Nature, 2003 Jun 26. PMID 12827206
    5. Getting (chromosomes) loaded--a new role for timeless. Golden A, et al. Dev Cell, 2003 Jul. PMID 12852847

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cohesin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cohesin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of mitotic cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Structural maintenance of chromosomes protein 3
    NP_001255118.1
    • Confirmed by transcript evidence
    NP_001255119.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11290904..11306247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268189.4 → NP_001255118.1  Structural maintenance of chromosomes protein 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255118.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B2FDA8, I2HAB3, Q9U2C1
      Conserved Domains (4) summary
      cd03272
      Location:3 → 151
      ABC_SMC3_euk; ATP-binding cassette domain of eukaryotic SMC3 proteins
      smart00968
      Location:534 → 646
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1198
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl21455
      Location:1093 → 1187
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001268190.3 → NP_001255119.1  Structural maintenance of chromosomes protein 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255119.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B2FDA8
      Conserved Domains (1) summary
      cl21455
      Location:217 → 311
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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