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    ints-1 Integrator complex subunit 1 RPB2-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 182280, updated on 9-Dec-2024

    Summary

    Official Symbol
    ints-1
    Official Full Name
    Integrator complex subunit 1 RPB2-binding domain-containing protein
    Primary source
    WormBase:WBGene00015499
    Locus tag
    CELE_C06A5.1
    See related
    AllianceGenome:WB:WBGene00015499
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in U2 snRNA 3'-end processing. Predicted to be part of integrator complex. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies. Orthologous to human INTS1 (integrator complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ints-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    19
    Sequence:
    Chromosome: I; NC_003279.8 (6011977..6022666)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA Neighboring gene COP9 signalosome complex subunit 2 Neighboring gene ncRNA Neighboring gene DUF4044 domain-containing protein Neighboring gene Chromatin modification-related protein MEAF6

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in U2 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in U2 snRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Integrator complex subunit 1 RPB2-binding domain-containing protein
    NP_491739.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6011977..6022666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059338.3NP_491739.2  Integrator complex subunit 1 RPB2-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491739.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01483
      Conserved Domains (1) summary
      pfam12432
      Location:308392
      DUF3677; Protein of unknown function (DUF3677)