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    Y87G2A.2 Acyl-coenzyme A thioesterase 8 [ Caenorhabditis elegans ]

    Gene ID: 173222, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y87G2A.2
    Official Full Name
    Acyl-coenzyme A thioesterase 8
    Primary source
    WormBase:WBGene00013594
    Locus tag
    CELE_Y87G2A.2
    See related
    AllianceGenome:WB:WBGene00013594
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid catabolic process. Predicted to be active in peroxisomal matrix. Orthologous to human ACOT8 (acyl-CoA thioesterase 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y87G2A.2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (13534737..13537066)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene Cysteine protease atg-4.1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene small monomeric GTPase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-coenzyme A thioesterase 8
    NP_493374.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13534737..13537066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060973.4 → NP_493374.2  Acyl-coenzyme A thioesterase 8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493374.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1Q5
      Conserved Domains (3) summary
      COG1946
      Location:8 → 285
      TesB; Acyl-CoA thioesterase [Lipid transport and metabolism]
      cd03444
      Location:182 → 285
      Thioesterase_II_repeat1; Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP) ...
      cd03445
      Location:16 → 105
      Thioesterase_II_repeat2; Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP) ...
    Nucleotide Protein
    Heading Accession and Version

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