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    atg-4.1 Cysteine protease atg-4.1 [ Caenorhabditis elegans ]

    Gene ID: 190777, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atg-4.1
    Official Full Name
    Cysteine protease atg-4.1
    Primary source
    WormBase:WBGene00013595
    Locus tag
    CELE_Y87G2A.3
    See related
    AllianceGenome:WB:WBGene00013595
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cysteine-type endopeptidase activity. Involved in aggrephagy and protein processing. Located in cytoplasm. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; head muscle; and nervous system. Orthologous to several human genes including ATG4A (autophagy related 4A cysteine peptidase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See atg-4.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (13536967..13542395, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene Acyl-coenzyme A thioesterase 8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene small monomeric GTPase Neighboring gene Valine--tRNA ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2. Hill SE, et al. Dev Cell, 2019 Apr 22. PMID 30880001, Free PMC Article
    2. Differential function of the two Atg4 homologues in the aggrephagy pathway in Caenorhabditis elegans. Wu F, et al. J Biol Chem, 2012 Aug 24. PMID 22767594, Free PMC Article
    3. MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9. Yang J, et al. Age (Dordr), 2013 Feb. PMID 22081425, Free PMC Article
    4. Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Lapierre LR, et al. Curr Biol, 2011 Sep 27. PMID 21906946, Free PMC Article
    5. Autophagy of germ-granule components, PGL-1 and PGL-3, contributes to DNA damage-induced germ cell apoptosis in C. elegans. Min H, et al. PLoS Genet, 2019 May. PMID 31125345, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-phosphatidylethanolamide deconjugating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-phosphatidylethanolamide deconjugating activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aggrephagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aggrephagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cysteine protease atg-4.1
    NP_001359618.1
    • Confirmed by transcript evidence
    NP_001368160.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13536967..13542395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373652.2 → NP_001359618.1  Cysteine protease atg-4.1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam03416
      Location:50 → 374
      Peptidase_C54; Peptidase family C54

    2. NM_001381245.1 → NP_001368160.1  Cysteine protease atg-4.1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      K8ESC5, Q9NA30
      Conserved Domains (1) summary
      pfam03416
      Location:77 → 401
      Peptidase_C54; Peptidase family C54
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    K8ESC5.1

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