slx-1 Structure-specific endonuclease subunit SLX1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: slx-1
Official Full Name: Structure-specific endonuclease subunit SLX1 homolog
Primary source: WormBase:WBGene00018909
Locus tag: CELE_F56A3.2
See related: AllianceGenome:WB:WBGene00018909
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables enzyme binding activity. Contributes to 3'-flap endonuclease activity; 5'-flap endonuclease activity; and crossover junction DNA endonuclease activity. Involved in several processes, including DNA metabolic process; meiotic chromosome separation; and positive regulation of embryonic development. Part of Slx1-Slx4 complex. Orthologous to human SLX1A (SLX1 homolog A, structure-specific endonuclease subunit) and SLX1B (SLX1 homolog B, structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See slx-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (5182736..5186236)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results are consistent with the existence of at least two redundant meiotic resolvase activities: one requiring HIM-6 and XPF-1, and the other dependent on SLX-1 and MUS-81.
Title: Combinatorial regulation of meiotic holliday junction resolution in C. elegans by HIM-6 (BLM) helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 nucleases.
SLX-1 shows a HIM-18/SLX-4-dependent endonuclease activity toward replication forks, 5'-flaps, and Holliday junctions. slx-1 mutants exhibit hypersensitivity to UV, nitrogen mustard, and camptothecin, but not gamma irradiation.
Title: SLX-1 is required for maintaining genomic integrity and promoting meiotic noncrossovers in the Caenorhabditis elegans germline.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F56A3.2 (e-PCR)
- UniSTS:314483

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
contributes_to 3'-flap endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to 5'-flap endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA endonuclease activity	IEA Inferred from Electronic Annotation more info
contributes_to crossover junction DNA endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in interstrand cross-link repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic DNA double-strand break processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic chromosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in resolution of meiotic recombination intermediates	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Slx1-Slx4 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Slx1-Slx4 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Slx1-Slx4 complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Structure-specific endonuclease subunit SLX1 homolog

NP_491541.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5182736..5186236

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059140.7 → NP_491541.1 Structure-specific endonuclease subunit SLX1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491541.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91351

Conserved Domains (1) summary

cd10455
Location:172 → 249

GIY-YIG_SLX1; Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its eukaryotic homologs