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    tac-1 Transforming acid coiled-coil-containing protein 1 [ Caenorhabditis elegans ]

    Gene ID: 175133, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tac-1
    Official Full Name
    Transforming acid coiled-coil-containing protein 1
    Primary source
    WormBase:WBGene00006381
    Locus tag
    CELE_Y54E2A.3
    See related
    AllianceGenome:WB:WBGene00006381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein domain specific binding activity. Involved in several processes, including pronuclear migration; regulation of microtubule polymerization or depolymerization; and spindle organization. Located in cytoplasm; kinetochore; and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tac-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (14752891..14753877, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Nonsense-mediated mRNA decay factor SMG9 Neighboring gene Activating signal cointegrator 1 complex subunit 3;SEC63 domain-containing protein Neighboring gene Secreted protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mos1-mediated transgenesis to probe consequences of single gene mutations in variation-rich isolates of Caenorhabditis elegans. Tarailo-Graovac M, et al. PLoS One, 2012. PMID 23155404, Free PMC Article
    2. The Caenorhabditis elegans Shugoshin regulates TAC-1 in cilia. Reed R, et al. Sci Rep, 2023 Jun 9. PMID 37296204, Free PMC Article
    3. ZYG-9ch-TOG promotes the stability of acentrosomal poles via regulation of spindle microtubules in C. elegans oocyte meiosis. Cavin-Meza G, et al. PLoS Genet, 2022 Nov. PMID 36449516, Free PMC Article
    4. ZYG-9, TAC-1 and ZYG-8 together ensure correct microtubule function throughout the cell cycle of C. elegans embryos. Bellanger JM, et al. J Cell Sci, 2007 Aug 15. PMID 17666432
    5. The arithmetic of centrosome biogenesis. Delattre M, et al. J Cell Sci, 2004 Apr 1. PMID 15075224

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Caenorhabditis elegans Shugoshin regulates TAC-1 in cilia.
      Title: The Caenorhabditis elegans Shugoshin regulates TAC-1 in cilia.
    2. The EFA-6 N-terminus binds the microtubule-associated proteins TAC-1/Transforming-Acidic-Coiled-Coil, and ZYG-8/Doublecortin-Like-Kinase, both of which are required for regenerative growth cone formation, and which act downstream of EFA-6.
      Title: Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase.
    3. These findings indicate that ZYG-9-TAC-1 and ZYG-8 act in a partially redundant manner to ensure correct microtubule assembly throughout the cell cycle of early C. elegans embryos.
      Title: ZYG-9, TAC-1 and ZYG-8 together ensure correct microtubule function throughout the cell cycle of C. elegans embryos.
    4. ZYG-9 and TAC-1 physically interact in vivo, and this interaction is important for the efficient localization of the ZYG-9/TAC-1 complex to centrosomes
      Title: Caenorhabditis elegans TAC-1 and ZYG-9 form a complex that is essential for long astral and spindle microtubules.
    5. TAC-1 is a major regulator of microtubule length in the C. elegans embryo.
      Title: TAC-1, a regulator of microtubule length in the C. elegans embryo.
    6. mutual stabilization between TACC and XMAP215 proteins is a key feature ensuring microtubule assembly in vivo
      Title: TAC-1 and ZYG-9 form a complex that promotes microtubule assembly in C. elegans embryos.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in astral microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pronuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transforming acid coiled-coil-containing protein 1
    NP_497059.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14752891..14753877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064658.8 → NP_497059.1  Transforming acid coiled-coil-containing protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497059.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECG0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ECG0.1

    Gene LinkOut

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